Results 181 to 190 of about 183,161 (215)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Examining the role of social workers within clinical metabolic genetics care. [PDF]

Mol Genet Metab Rep
Shim S, Cory D, Wixson G, Hata A, Werner-Lin A.   +4 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Young ERC Resuscitation Science Masterclass Journal Club article: the ARREST trial. [PDF]

Resusc Plus
Gallob F, Bürgstein E, Jorge-Soto C.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Appropriateness of patients transferred with orthopaedic injuries: a retrospective study of a Level III teaching hospital. [PDF]

OTA Int
O'Brien C, Jelinek T, Young A, Phelps C, Patel A, Basener C, Scott J.   +6 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Psychological distress among dialysis patients during the COVID-19 Omicron pandemic: risk and protective factors across hemodialysis and peritoneal dialysis. [PDF]

Front Psychiatry
Chang CY, Tsai SF, Huang LL, Chung MC, Chen SY, Chou YH, Lin HY, Chen CH, Yeh TF.   +8 more
europepmc   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Evaluation of an intelligent inpatient transportation system in a large tertiary hospital: a full implementation case review. [PDF]

Front Public Health
Jiang C, Zhu H, Deng L, Shu Y, Zhou X, Tong L, Zhou Y, Ye Y, Cao M.   +8 more
europepmc   +1 more source