Results 61 to 70 of about 14,272 (175)
Transporters involved in hepatobiliary transport of drugs.
近年,ヒト肝臓において非常に多くのトランスポーターが同定・機能解析されるにつれて,トランスポーターの遺伝子多型や薬物間相互作用による機能変動が薬物動態に与える影響を明らかにするための臨床研究も続々と報告されてきている.それに伴い,異物解毒システムの中でのトランスポーターの重要性が広く認知されてきた.代謝によって消失すると考えられてきた薬物の中にも肝取り込みトランスポーターの基質が含まれていることが明らかとなり,取り込みトランスポーターの機能変動が薬物動態の変化につながる事例が複数報告されてきている.本稿では,ヒト肝臓に発現する主な薬物トランスポーターを紹介すると共に,これらの遺伝子多型・薬物間相互作用が薬物動態や薬効・副作用に与える影響について概説することを目指した.
openaire +3 more sources
Metro stations are essential for daily commuting, but overcrowding due to increased demand can severely impact infrastructure quality and passenger experience.
Sebastian Seriani +9 more
doaj +1 more source
Infrastructure management is one of the main problems faced by railway managers. Generally, decision making is based on track geometry measurements made with recording machines.
Jorge Rojas-Vivanco +6 more
doaj +1 more source
Pediatric patient fixation for air aeromedical transport in rotary-wing aircraft: a professional experience report. [PDF]
Batista EA, Colleti Junior J.
europepmc +1 more source
[Implementation of the Brazilian National Health Policy for Persons with Disabilities in Rio de Janeiro, Brazil: evaluation of access to oral health]. [PDF]
Alves FNM, O'Dwyer G.
europepmc +1 more source
Spatiotemporal trends in hospital morbidity indicators due to road traffic injuries in the state of Piauí, Brazil, 2010-2023. [PDF]
Bastos FGT +4 more
europepmc +1 more source
Position Statement on Cardiovascular Emergencies at Sporting Events - 2026. [PDF]
Ritt LEF +17 more
europepmc +1 more source
Barriers to access to health services for people with orphan-rare diseases in Huila, Colombia [PDF]
Troche IY +3 more
europepmc +1 more source

