Results 51 to 60 of about 52,328 (310)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
SURVEY METHODS FOR TRANSPORT PLANNING
Transportes, 1997 A literatura técnica de planejamento de transportes se enriquece com o livro de Richardson, Ampt e Meyburg (1995) sobre Métodos de Pesquisa para Planejamento de Transportes.
Orlando Strambi
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Boletim Transportes em Foco ano 3 n.4 Jan 2022
, 2022 A quarta edição do boletim Transporte em Foco apresenta uma inovação: PODCAST FGV Transportes! Apresentam-se as três últimas gravações que abordam temas como marco das ferrovias, segurança jurídica na infraestrutura de transportes, além dos cenários e ...
FGV Transportes
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Optimizing humanitarian water logistics: facility location and routing in drought-affected Brazilian semiarid northeast [PDF]
Journal of Humanitarian Logistics and Supply Chain ManagementPurposeThis study aims to present a two-step optimization procedure aimed at enhancing the efficiency of emergency drinking water distribution via tanker trucks in drought-prone regions, specifically focusing on Brazil’s semiarid northeast.Design ...
Dayanna Rodrigues da Cunha Nunes +4 more
doaj +1 more source
Webinar: Lançamento da Revista Brasileira de Transportes - RBT
, 2021 Com o intuito de contribuir, de maneira incisiva e destacada, para a evolução do pensamento estratégico e o desenvolvimento acadêmico, empresarial, econômico e social do país, a Fundação Getulio Vargas, por intermédio de seu Centro de Estudos em ...
FGV Transportes
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Plan de estaciones de transporte de viajeros por carretera de Andalucía
, 1991 D. L.: SE-2092-1991Andalucía. Consejería de Obras Públicas y Transportes; Andalucía.
Andalucía. Dirección General de Transportes
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