Results 191 to 200 of about 2,371,477 (389)

GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss

open access: yesAdvanced Science, EarlyView.
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng   +11 more
wiley   +1 more source

Early life exposures, neurodevelopmental disorders, and transposable elements

open access: yesNeurobiology of Stress, 2019
Transposable elements make up a much larger portion of the genome than protein-coding genes, yet we know relatively little about their function in the human genome.
Hannah E. Lapp, Richard G. Hunter
doaj  

Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization

open access: yesAdvanced Science, EarlyView.
This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao   +15 more
wiley   +1 more source

Species identification in fish meal from urban fisheries biomass with DNA metabarcoding analysis

open access: yesAquaculture, Fish and Fisheries, Volume 2, Issue 6, Page 562-571, December 2022., 2022
Fish species constructing fish meal (FM) made from urban fisheries biomass, which is fisheries by‐products collected downstream in the seafood supply chain were detected with a DNA metabarcoding method. 81–122 species were detected in the FM, and fish species indicated as Critically Endangered (CR) or Endangered (EN) on the International Union for ...
Atsushi Ido, Takeshi Miura
wiley   +1 more source

The transposable element Mdg3 in Drosophila melanogaster is flanked with the perfect direct and mismatched inverted repeats [PDF]

open access: bronze, 1980
A.A. Bayev   +5 more
openalex   +1 more source

In‐Depth Cell‐Type‐Specific Proteome Landscape of the Brain from Human Amyloid‐β Overexpression Mouse Model

open access: yesAdvanced Science, EarlyView.
In situ Cell‐type‐specific proteome Analysis using antibody‐mediated Biotinylation (iCAB) is a method that directly targets and analyzes proteins in specific cell types within tissue. Applied to 5xFAD mice, iCAB identifies ≈8000 cell‐type‐specific proteins, revealing unique pathways in neurons, astrocytes, and microglia.
Taekyung Ryu   +6 more
wiley   +1 more source

Structural Diversity of Mitochondria in the Neuromuscular System across Development Revealed by 3D Electron Microscopy

open access: yesAdvanced Science, EarlyView.
Mitochondria across the entire neuromuscular system have been comprehensively reconstructed at different developmental stages using 3D electron microscopy. Fundamental structural principles related to synaptic function are preserved across development, and these morphologies are adapted to ensure effective neural circuit function.
J. Alexander Bae   +9 more
wiley   +1 more source

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