Results 261 to 270 of about 100,531 (319)

The High‐Altitude Adaptation Characteristics of Microbiota‐Host Cross‐Talk in Yak Gastrointestinal Track

Advanced Science, EarlyView.
In this study, a single‐cell atlas of 117,019 yak gastrointestinal cells across 54 subtypes identified HNF4A and SREBF2 as key transcription factors targeting MYO6 gene. Cross‐species and multi‐omics analyses reveals epithelial cells as key regulators that, through interactions with microbes, particularly Bacillus, facilitate flexible energy supply and
Chun Huang, Minghao Zhang, Qingbo Zheng, Qinran Yu, Guowu Yang, Wenwen Ren, Xiaoming Ma, Yongfu La, Pengjia Bao, Min Chu, Xian Guo, Chunnian Liang, Ping Yan   +12 more
wiley   +1 more source

Investigating the Impact of Whole-Genome Duplication on Transposable Element Evolution in Teleost Fishes. [PDF]

Genome Biol Evol
Mallik R, Wcisel DJ, Near TJ, Yoder JA, Dornburg A.   +4 more
europepmc   +1 more source

High‐Resolution Multiplexed Sequencing of Single‐Cell Full‐length Transcriptome Via Combinational Barcoded Tn5 Transposon Insertion

Advanced Science, EarlyView.
CBTi‐seq is reported, leveraging Tn5 transposase‐mediated molecular assembly of combinatorial barcodes and UMIs for high‐resolution multiplexed sequencing of the full‐length transcriptome in single cells. This approach achieves molecular resolution by end‐to‐end sequencing, enabling reconstruction of splice variants and accurate quantification of ...
Liyong He, Kaitong Dang, Qian Sun, Wenjia Wang, Wenbo Li, Wenyi Zhang, Kaiqiang Ye, Handong Wang, Zhengyue Li, Yan Guo, Zheng Li, Chencheng Yao, Peng Li, Yan Huang, Xiangwei Zhao   +14 more
wiley   +1 more source

LocusMasterTE: integrating long-read RNA sequencing improves locus-specific quantification of transposable element expression. [PDF]

Genome Biol
Lee S, Barbour JA, Tam YM, Yang H, Huang Y, Wong JWH.   +5 more
europepmc   +1 more source

Efficiency Recalibrates Social‐Emotional Trade‐Offs Behind Partner Choice in Direct Reciprocity through Intention‐Specific Neural Bases

Advanced Science, EarlyView.
Bridging the gap between two crucial mechanisms of cooperation, namely direct reciprocity and partner choice, this study reveals the neurocognitive bases underlying how individuals prioritize reciprocal partner when receiving help from multiple benefactors with diverse intentions and reciprocal efficiency. The efficiency‐driven reciprocal decisions are
Rui Liao, Xintong Li, Xuqi Liu, Yu Nan, Xiaolin Zhou, Xiaoxue Gao   +5 more
wiley   +1 more source

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source

The Importance of Being Imperfect: Structure and Function of Bacterial Amyloid

Advanced Science, EarlyView.
Functional bacterial amyloids such as CsgA and FapC have been widely studied to understand the relationship between aggregation and function. The recently solved structure of FapC reveals a Greek‐key motif in which extensive hydrogen bonding and packing interactions formed by residues in conserved imperfect repeats stabilize a β‐solenoid core.
Samuel Peña‐Díaz, Yanting Jiang, Zhefei Zhang, Anders Daugberg, Pedro Ferreira, Marcos López Hernández, Chandrika Mittal, Maria Joao Ramos, Jan Skov Pedersen, Morten Kam Dahl Dueholm, Cao Qin, Huabing Wang, Daniel E. Otzen   +12 more
wiley   +1 more source

Widespread transposable element dysregulation in human aging brains with Alzheimer's disease. [PDF]

Alzheimers Dement
Feng Y, Yang X, Hou Y, Zhou Y, Leverenz JB, Eng C, Pieper AA, Goate A, Shen Y, Cheng F.   +9 more
europepmc   +1 more source

Quantitative Assessment of Randomized DNA Base Sequences Using Multi‐Model Physical Analysis for High‐Fidelity Data Storage

Advanced Science, EarlyView.
This study quantitatively evaluates randomized DNA sequence design for digital data storage using three physics‐based models. By applying encoding schemes with strict homopolymer constraints, the framework improves base randomness, GC balance, and error resilience. Experimental validation via PCR and Sanger sequencing confirms 95–98% decoding accuracy,
Seongjun Seo, Thi Hong Nhung Vu, Anshula Tandon, Suyoun Park, Thi Bich Ngoc Nguyen, Shinsuke Kawai, Sung Ha Park   +6 more
wiley   +1 more source

Solid Harmonic Wavelet Bispectrum for Image Analysis

Advanced Science, EarlyView.
The Solid Harmonic Wavelet Bispectrum (SHWB), a rotation‐ and translation‐invariant descriptor that captures higher‐order (phase) correlations in signals, is introduced. Combining wavelet scattering, bispectral analysis, and group theory, SHWB achieves interpretable, data‐efficient representations and demonstrates competitive performance across texture,
Alex Brown, Mathilda Avirett‐Mackenzie, Carolin Villforth, Georgios Exarchakis   +3 more
wiley   +1 more source