Results 91 to 100 of about 265,737 (174)
Integrated in silico discovery of thymoquinone analogs as potent Keap1 inhibitors for ALS therapy. Using validated QSAR, docking, and 200 ns MD simulations, we identified brain‐penetrant leads (CHEMBL3416163, CHEMBL4636830, and CHEMBL221598) with binding affinities up to fourfold stronger than thymoquinone, offering a targeted strategy to restore redox
Jabir C. Nalicho +3 more
wiley +1 more source
Experiments with stored relativistic exotic nuclei
Beams of relativistic exotic nuclei were produced, separated and investigated with the combination of the fragment separator FRS and the storage ring ESR.
Geissel, H. +3 more
core
Technologies for engineering repetitive DNA
Abstract Repetitive DNA, a fundamental architectural element of genomes, is widespread across organisms and comprises about 54% of the human genome. With advances in long‐read sequencing and bioinformatics approaches, highly repetitive sequences can now be characterized in depth.
Shuting Ma, Yali Cui, Yi Wu
wiley +1 more source
Molecular insights and translational opportunities to enhance heat tolerance in rice
Abstract Heat stress is an increasingly serious threat to rice (Oryza sativa L.) productivity, yet the genetic and regulatory architecture underlying thermotolerance remain poorly resolved and fragmented across studies. Earlier research focused on individual pathways or specific developmental stages; however, recent advances now support an integrated ...
Prabhat Rana +7 more
wiley +1 more source
Integrated Engineering of CAR‐T Cells for Solid Tumours
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang +5 more
wiley +1 more source
Spanish‐Speaking Secondary Students Reading and Spelling in English as a Foreign Language
ABSTRACT Proficiency in English reading and spelling is essential, as many professional environments require both spoken and written skills. Literacy development in English as a foreign language poses challenges for learners whose first language is transparent, such as Spanish, due to the complexity and inconsistency of English orthography.
Paz Suárez‐Coalla +3 more
wiley +1 more source
Physical Activity and Purkinje Cells: Mechanisms of Cerebellar Plasticity and Neuroprotection. [PDF]
Palmeri N +6 more
europepmc +1 more source
Over the past two decades, ecologically valid music paradigms have shown that mismatch negativity (MMN) reflects a primitive musical intelligence, indexing hierarchical auditory predictions in music that parallel those observed in speech. MMN captures processing from early sensory detection in superior temporal cortices to higher order frontal ...
Elvira Brattico +3 more
wiley +1 more source
Host-transposable element coexistence: a matter of resistance, tolerance and trade-off. [PDF]
Chambeyron S +4 more
europepmc +1 more source
ABSTRACT Marine fish commonly move across distinct habitats throughout their lifetimes, particularly during larval stages, when they are particularly difficult to track. Such transitions are necessary as environmental demands and predation pressures change dramatically with increases in body size.
Yuan Tian Chou +3 more
wiley +1 more source

