Results 161 to 170 of about 84,372 (267)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Robotic uterine transposition for fertility preservation in patients undergoing pelvic radiotherapy: a narrative review of surgical evolution, technical strategies, and emerging evidence. [PDF]

J Robot Surg
D'Indinosante M, Parisi G, Bruno M, Innocenzi C, Pavone M, Peters I, Corrado G, Querleu D, Fanfani F, Fagotti A, Bizzarri N.   +10 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Major Aortopulmonary Collateral Artery as a Rare Cause of Heart Failure in a Neonate with Transposition of the Great Arteries: An Unexpected Turn in an Otherwise Routine Case. [PDF]

J Cardiovasc Dev Dis
Parezanovic V, Andric D, Chadikovski V, Stojanovikj V, Madzoska J, Trpkovska V, Stefanovic I.   +6 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Case Report: Leadless pacemaker implantation in patient with Senning procedure for dextro-transposition of the great arteries. [PDF]

Front Cardiovasc Med
Kile H, Fishberger S.
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Open surgery appears to be the preferred treatment in patients with nutcracker syndrome: A vascular low frequency disease consortium analysis. [PDF]

J Vasc Surg Venous Lymphat Disord
Suckow BD, Ponukumati A, Wang L, Columbo J, Stone D, Powell R, West-Livingston LN, Shortell CK, Etkin Y, Paci SPR, Hemingway JF, Meissner MH, Gomez-Sanchez CM, Flanagan CP, Bove PG, Long GW, Smith BK, Gombert A, Barbati ME, Aulivola B, Stilo F, Montelione N, De Caridi G, Benedetto F, McGinigle KL, Alsaarayreh M, Szeberin Z, Zatyko DZ, Amankwah KS, Joh JH, Cho S, Schermerhorn ML, Yadavalli SD, Zhou W, Tolson J, Lawrence P, Woo K, Vascular Low Frequency Disease Consortium.   +37 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Laparoscopic management of endometrioma following ovarian transposition during radical hysterectomy [PDF]

Journal of Medicine and Life Science
Chul Min Park
doaj   +1 more source