Results 211 to 220 of about 8,468 (261)

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

Unveiling ccTGA complexity: CMR and 3D modelling for surgical planning-a case series. [PDF]

Eur Heart J Imaging Methods Pract
Cao I, Cetera V, Viganò G, Marrone C, Torracchi L, Poli V, Celi S, Capellini K, Gasparotti E, Cantinotti M, Monteleone A, Festa P, Ait-Ali L, Pak V.   +13 more
europepmc   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Endotracheal bleeding after arterial switch operation: Think of a bleeding major aortopulmonary collateral artery. [PDF]

Ann Pediatr Cardiol
von der Emde B, Di Pasquale L, Cesnjevar R, Kretschmar O, Knirsch W, Dave H.   +5 more
europepmc   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Pancreatic cancer in situs inversus totalis: case presentation and literature review. [PDF]

Int J Surg Case Rep
Filippo B, Prioriello C, Rastelli E, Corso RM, Orlandi E, Giuffrida M.   +5 more
europepmc   +1 more source

Tachycardia-Induced Cardiomyopathy in ccTGA: Successful Ablation of Incessant Atrial Tachycardia From Right Pulmonary Sinus Cusp. [PDF]

JACC Case Rep
Sun Y, Gong H, Wang Z, Dai S, Xiao X, Ma C, Yu X, Gao L, Xia Y, Yin X.   +9 more
europepmc   +1 more source

Shortness of breath on a mustard patient: multidisciplinary approach improves outcomes. [PDF]

J Cardiothorac Surg
Casallas-Gutierrez I, Chalela T, Sandoval N, Acosta-Izquierdo L, Forero J, Luna-Pisciotti S, Guerrero-Chalela CE.   +6 more
europepmc   +1 more source

Surgical management of a patient with mirror-image dextrocardia with situs inversus, atrial septal defect, moderate tricuspid regurgitation, and moderate to severe pulmonary hypertension: a case report. [PDF]

J Cardiothorac Surg
Chen P, Gong Q, Lu B, Zheng G, Ke X, Chen C.   +5 more
europepmc   +1 more source

Adolescent presentation of L-type ccTGA with pulmonary valve hypoplasia and RV dysfunction: from cardiogenic shock to surgical repair. [PDF]

Egypt Heart J
Jain S, Kumar D, Kumar N, Shrivastava PM.   +3 more
europepmc   +1 more source