Results 311 to 320 of about 60,909 (346)

Investigation into thiol conjugation of transthyretin in hereditary transthyretin amyloidosis

European Journal of Clinical Investigation, 1998
BackgroundFor all forms of amyloidosis, the amyloid‐generating mechanism is unknown. Familial amyloidotic polyneuropathy type I is caused by a variant transthyretin (TTR Met‐30). As electrospray ionization mass spectrometry (ESI‐MS) discloses both thiol‐conjugated and ‐unconjugated forms of wild‐type and variant TTR, we wanted to investigate the ...
Yukio Ando, P.I. Ohlsson, Anders Olofsson, Ole B. Suhr, Erik Lundgren, Masayuki Ando, Karin Andersson, Gösta Holmgren   +7 more
openaire   +3 more sources

Prevalence and clinical outcomes of transthyretin amyloidosis: a systematic review and meta‐analysis

European Journal of Heart Failure, 2022
Systematic evidence on the prevalence and clinical outcome of transthyretin amyloidosis (ATTR) is missing. We explored: (i) the prevalence of cardiac amyloidosis in various patient subgroups, (ii) survival estimates for ATTR subtypes, and (iii) the ...
A. Antonopoulos, I. Panagiotopoulos, A. Kouroutzoglou, G. Koutsis, P. Toskas, G. Lazaros, K. Toutouzas, D. Tousoulis, K. Tsioufis, C. Vlachopoulos   +9 more
semanticscholar   +1 more source

Structural and functional evolution of transthyretin and transthyretin‐like proteins

Proteins: Structure, Function, and Bioinformatics, 2006
AbstractTransthyretin (TTR) is a tetrameric protein involved in the distribution of thyroid hormones in vertebrates. The amino acid sequence of TTR is highly conserved across vertebrates. Hypothetical TTR‐like proteins (TLPs) were inferred from the identification of genes in nonvertebrate species. Here, we identified five motifs defining TLPs and three
Vladimir A Likic, Hannah M. Wright, Sarah C. Hennebry, Samantha J. Richardson   +3 more
openaire   +3 more sources

Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy.

New England Journal of Medicine
BACKGROUND Transthyretin amyloidosis with cardiomyopathy (ATTR-CM) is a progressive, fatal disease. Vutrisiran, a subcutaneously administered RNA interference therapeutic agent, inhibits the production of hepatic transthyretin.
M. Fontana, J. Berk, J. Gillmore, Ronald M. Witteles, M. Grogan, B. Drachman, Thibaud Damy, Pablo Garcia-Pavia, Jorg Taubel, Scott D. Solomon, Farooq H. Sheikh, Nobuhiro Tahara, J. González-Costello, Kenichi Tsujita, C. Morbach, Zoltán Pozsonyi, M. C. Petrie, D. Delgado, P. van der Meer, Andrew Jabbour, A. Bondue, Darae Kim, Olga Azevedo, Steen Hvitfeldt Poulsen, Ali Yilmaz, Ewa A. Jankowska, Vincent Algalarrondo, Andrew Slugg, Pushkal P. Garg, Katherine L. Boyle, E. Yureneva, Nancy Silliman, Lilli Yang, Jihong Chen, S. Eraly, J. Vest, M. S. Maurer   +36 more
semanticscholar   +1 more source

Transthyretin-Related and Transthyretin-like Proteins

2009
Bioinformatics programs are highly accurate in identifying protein families directly from protein sequences, even when the sequence identity is very low. The transthyretin-related proteins (TRPs) are one example of a protein family that has been identified.
A. Elisabeth Sauer-Eriksson, Anna Linusson, Erik Lundberg   +2 more
openaire   +2 more sources

Transthyretin and the human placenta

Placenta, 2013
Since its discovery, transthyretin (TTR) has been regarded as an important hepatically derived protein carrier of thyroid hormones and retinol in blood. However, in more recent years it has been shown that TTR has other important functions. TTR is abundant in cerebrospinal fluid, where it may be involved in transport of thyroid hormones into the brain.
Kelly Landers, Robin H. Mortimer, Kerry Richard, Kerry Richard   +3 more
openaire   +4 more sources

Cardiac Amyloidosis Due to Transthyretin Protein: A Review.

Journal of the American Medical Association (JAMA)
Importance Systemic amyloidosis from transthyretin (ATTR) protein is the most common type of amyloidosis that causes cardiomyopathy. Observations Transthyretin (TTR) protein transports thyroxine (thyroid hormone) and retinol (vitamin A) and is ...
F. Ruberg, Mathew S. Maurer
semanticscholar   +1 more source

Transthyretin Cardiac Amyloidosis

Current Cardiology Reports, 2017
Transthyretin (TTR)-related cardiac amyloidosis is a progressive infiltrative cardiomyopathy that mimics hypertensive, hypertrophic heart disease and may go undiagnosed. Transthyretin-derived amyloidosis accounts for 18% of all cases of cardiac amyloidosis.
Anit K. Mankad, Keyur B. Shah
openaire   +3 more sources

Skin amyloid deposits and nerve fiber loss as markers of neuropathy onset and progression in hereditary transthyretin amyloidosis

European Journal of Neurology, 2022
This study was undertaken to assess skin biopsy as a marker of disease onset and severity in hereditary transthyretin amyloidosis with polyneuropathy (ATTRv‐PN), a treatable disease.
L. Leonardi, C. Adam, G. Beaudonnet, D. Beauvais, C. Cauquil, A. Not, Olivier Morassi, A. Benmalek, Olivier Trassard, A. Echaniz-Laguna, D. Adams, C. Labeyrie   +11 more
semanticscholar   +1 more source

Hereditary transthyretin amyloidosis associated with a transthyretin variant Thr59Arg

Amyloid, 2017
Hereditary transthyretin (TTR) amyloidosis is characterized by ATTR amyloid deposits in various tissue sites and organs, such as peripheral nerves, heart, gastrointestinal tract, kidneys, eyes, and...
Tetsuya Watanabe, Yohei Misumi, Takafumi Akagami, Masayoshi Tasaki, Yukio Ando, Shinichi Hirotani, Mitsuharu Ueda, Tomotaka Ando, Satoru Shinriki, Konen Obayashi, Taro Yamashita   +10 more
openaire   +3 more sources