Results 31 to 40 of about 14,196 (197)

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

A rare case of synchronous renal cell carcinoma of the bladder presenting with gross hematuria

Rare Tumors, 2013
A 57-year old man was referred to the Urology Department due to gross hematuria; abdominal ultrasound revealed an unspecific solid tumor of the left bladder wall.
Jens Bedke, Arnulf Stenzl, Marcus Scharpf, Stephan Kruck   +3 more
doaj   +1 more source

Isocyanate‐Modified Melatplatin(IV) Enhances Antitumor Efficacy via TCF4/COL6A3‐Mediated Extracellular Matrix Remodeling and cGAS‐STING Pathway Activation in Bladder Cancer

Advanced Science, EarlyView.
A series of melatonin‐conjugated platinum(IV) prodrugs was functionalized with isocyanate chains (compounds 5‒12). MP‐12C (compound 11) was identified as the lead candidate, with optimal potency and safety. MP‐12C exhibited greater efficacy than cisplatin by increasing intracellular uptake, reshaping the extracellular matrix, activating the cGAS‐STING ...
Linhui Wang, Xiaomeng Liu, Tao Zhu, Zirun Su, Ruiping Liu, Zhe Li, Kaixuan Du, Kaipeng Jia, Chong Fu, Yuda Lin, Zihan Xue, Zhe Zhang, Chong Shen, Yunkai Qie, Zhouliang Wu, Zhiheng Liu, Kangkang Liu, Jingyuan Xu, Hailong Hu   +18 more
wiley   +1 more source

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

Serial H&E Pathology Reveals Progression‐Associated Nuclear Size Drift as a Longitudinal Digital Readout of Bladder Cancer Evolution

Advanced Science, EarlyView.
Routine serial H&E specimens from bladder cancer are converted into paired T0/T1 digital pathology readouts of tumor evolution. Progression is associated with longitudinal nuclear drift, with nuclear size‐related changes most evident in the independent confirmation cohort, alongside a broader spatial burden of increased nuclear area and biological ...
Xing Liu, Zhen‐Duo Shi, Gong‐Cheng Wang, Jian‐Ming Wang, Ying Liu, Yi Gong, Xuan Lin, Di Wu, Shi‐Chao Zhuo, Han Han, Yi‐Bing Shi, Fan‐Lai Meng, Yu Zhang, Zhi‐Gang Jia, Cong‐Hui Han   +14 more
wiley   +1 more source

Paraganglioma in the bladder: a case report

Journal of Medical Case Reports, 2017
Background Paraganglioma is an extra site of pheochromocytoma. Paraganglioma in the bladder is a very rare disease accounting for 0.06% of all bladder tumors.
Genta Iwamoto, Takashi Kawahara, Mikiko Tanabe, Sahoko Ninomiya, Daiji Takamoto, Taku Mochizuki, Shinnosuke Kuroda, Teppei Takeshima, Koji Izumi, Yusuke Hattori, Jun-ichi Teranishi, Yasushi Yumura, Yasuhide Miyoshi, Hiroji Uemura   +13 more
doaj   +1 more source

Comparison of the efficacy and feasibility of en bloc transurethral resection of bladder tumor versus conventional transurethral resection of bladder tumor

Medicine, 2016
The aim of this meta-analysis was to compare the feasibility of en bloc transurethral resection of bladder tumor (ETURBT) versus conventional transurethral resection of bladder tumor (CTURBT).Relevant trials were identified in a literature search of MEDLINE, EMBASE, Cochrane Library, Web of Science, and Google Scholar using appropriate search terms ...
Wu, Yu-Peng, Lin, Ting-Ting, Chen, Shao-Hao, Xu, Ning, Wei, Yong, Huang, Jin-Bei, Sun, Xiong-Lin, Zheng, Qing-Shui, Xue, Xue-Yi, Li, Xiao-Dong   +9 more
openaire   +2 more sources

Clinical Translation of Patient‐Derived Organoids: Perspectives for Personalized Therapy in Cancer

International Journal of Cancer, EarlyView.
ABSTRACT Patient‐derived organoids (PDO) are accelerating precision medicine. These biological platforms allow for the autologous in vitro expansion of material from cancer patients in a considerably short period of time. These three‐dimensional models can faithfully recapitulate aspects of tissue heterogeneity, architecture, and relevant cellular ...
Haiyan Yue, Daniele Carchidi, Philipp Schmucker, Roland Seiler, Bernhard Kiss, Catarina Macedo‐Silva, Marianna Kruithof‐de Julio   +6 more
wiley   +1 more source

Tumor-Associated Macrophages Provide Significant Prognostic Information in Urothelial Bladder Cancer.

PLoS ONE, 2015
Inflammation is an important feature of carcinogenesis. Tumor-associated macrophages (TAMs) can be associated with either poor or improved prognosis, depending on their properties and polarization. Current knowledge of the prognostic significance of TAMs
Minna M Boström, Heikki Irjala, Tuomas Mirtti, Pekka Taimen, Tommi Kauko, Annika Ålgars, Sirpa Jalkanen, Peter J Boström   +7 more
doaj   +1 more source

Expression and prognostic value of carbonic anhydrase IX (CA-IX) in bladder urothelial carcinoma

BMC Urology, 2022
Objective To investigate the expression intensity of carbonic anhydrase IX (CA-IX) in bladder urothelial carcinoma and its predictive value for the recurrence after transurethral resection of bladder tumor.
An-Ping Xiang, Xiao-Nong Chen, Peng-Fei Xu, Si-Hai Shao, Yue-Fan Shen   +4 more
doaj   +1 more source