Results 51 to 60 of about 420,206 (299)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Prospects for measuring the electric dipole moment of the electron using electrically trapped polar molecules

, 2009
Heavy polar molecules can be used to measure the electric dipole moment of the electron, which is a sensitive probe of physics beyond the Standard Model.
Hinds, E. A., Hudson, J. J., Sauer, B. E., Tarbutt, M. R.   +3 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Assessment of sediment trap collection efficiency [PDF]

Limnology and Oceanography, 1979
Theoretical considerations of the effects of turbulence around and within sedimentation traps show that the aspect ratio (height:mouth opening) of the traps is important in determining particle retention. Collection efficiency and comparative measures of deposition per unit area in traps of various design were independent of this ratio in cairn water ...
Barry T. Hargrave, Noel M. Burns
openaire   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

A Laboratory Dataset on Transport and Deposition of Spherical and Cylindrical Large Microplastics for Validation of Numerical Models

Journal of Marine Science and Engineering
The widespread presence of micro-sized plastic pollution has raised concerns due to their unique physical and toxic properties. Each year, water bodies carry millions of tons of plastic into the ocean.
Mostafa Bigdeli, Abdolmajid Mohammadian, Abolghasem Pilechi   +2 more
doaj   +1 more source

Coulomb crystal mass spectrometry in a digital ion trap [PDF]

, 2015
We present a mass spectrometric technique for identifying the masses and relative abundances of Coulomb-crystallized ions held in a linear Paul trap.
Deb, Nabanita, Heazlewood, Brianna R, Keller, Matthias, Pollum, Laura L, Rennick, Christopher J, Smith, Alexander D, Softley, Timothy P   +6 more
core   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Measurement of the Neutron Lifetime by Counting Trapped Protons in a Cold Neutron Beam

, 2004
A measurement of the neutron lifetime $\tau_{n}$ performed by the absolute counting of in-beam neutrons and their decay protons has been completed. Protons confined in a quasi-Penning trap were accelerated onto a silicon detector held at a high potential
A. D. Carlson, A. Lamberty, D. M. Gilliam, F. E. Wietfeldt, G. L. Greene, I. S. Towner, I. Shipsey, J. Byrne, J. D. Jackson, J. Pauwels, J. S. Nico, J. Van Gestel, M. Kretzschmar, M. S. Dewey, P. Ball, P. E. Spivak, P. R. Huffman, R. D. Scott, R. Eykens, V. V. Nezvizhevskii, W. M. Snow, W. Mampe, W. Paul, X. Fei   +23 more
core   +1 more source