Results 71 to 80 of about 420,206 (299)

Comparing the Efficiency of Insect Traps

Bulletin of Entomological Research, 1951
An experiment is described in which three light traps were tested for relative efficiency by having three locations in a wood and moving the traps each day so that over a period of three nights each trap had been once in each position. The actual number of moths caught were converted to a logarithmic scale and the mean log. (i.e., log. of the geometric
openaire   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Diffraction limited optics for single atom manipulation

, 2006
We present an optical system designed to capture and observe a single neutral atom in an optical dipole trap, created by focussing a laser beam using a large numerical aperture N.A.=0.5 aspheric lens.
Armellin, C., Browaeys, A., Fournet, P., Grangier, P., Lamare, M., Lance, A. M., Marion, H., Mercier, R., Messin, G., Sortais, Y. R. P., Tuchendler, C.   +10 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Geometric light trapping with a V-trap for efficient organic solar cells

Optics Express, 2013
The efficiency of today's most efficient organic solar cells is primarily limited by the ability of the active layer to absorb all the sunlight. While internal quantum efficiencies exceeding 90% are common, the external quantum efficiency rarely exceeds 70%. Light trapping techniques that increase the ability of a given active layer to absorb light are
Kim, Soo Jin, Margulis, George Y., Rim, Seung-Bum, Brongersma, Mark L., McGehee, Michael D., Peumans, Peter   +5 more
openaire   +3 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A simple and efficient all-optical production of spinor condensates

, 2013
We present a simple and optimal experimental scheme for an all-optical production of a sodium spinor Bose-Einstein condensate (BEC). With this scheme, we demonstrate that the number of atoms in a pure BEC can be greatly boosted by a factor of 5 in a ...
Jiang, J., Jiang, N., Liu, Y., Webb, M., Yang, H., Zhao, L.   +5 more
core   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Ion detection in the photoionization of a Rb Bose-Einstein condensate

, 2010
Two-photon ionization of Rubidium atoms in a magneto-optical trap and a Bose-Einstein condensate (BEC) is experimentally investigated. Using 100 ns laser pulses, we detect single ions photoionized from the condenstate with a 35(10)% efficiency.
A Chotia, Courtade E, D Ciampini, E Arimondo, F Fuso, I I Ryabtsev, J Radogostowicz, Löw R Raitzsch U Heidemann R Bendkowsky V Butscher B Grabowski A Pfau T, M G Bason, M Viteau, Mazets I E, N Malossi, O Morsch, Potvliege R M, Viteau M Radogostowicz J Chotia A Bason M G Malossi N Ciampini D Morsch O Arimondo E   +14 more
core   +3 more sources