Results 211 to 220 of about 3,680 (277)

Neuromuscular and neuromechanical assessments of respiratory performance in the mdx mouse model of Duchenne muscular dystrophy across the natural history of disease

open access: yesExperimental Physiology, EarlyView.
Abstract Duchenne muscular dystrophy (DMD) is a severe life‐limiting X‐linked neuromuscular disorder characterised by progressive skeletal muscle degeneration and respiratory failure. The mdx mouse, lacking dystrophin, is the most widely used preclinical model of DMD, yet the trajectory of respiratory dysfunction in this model remains incompletely ...
Michael N. Maxwell   +4 more
wiley   +1 more source

Pharmacokinetics of Pegaspargase with a Limited Sampling Strategy for Asparaginase Activity Monitoring in Children with Acute Lymphoblastic Leukemia. [PDF]

open access: yesPharmaceutics
Matteo C   +21 more
europepmc   +1 more source

The impact of type 2 diabetes on tendon material properties and locomotor function in the db/db mouse

open access: yesExperimental Physiology, EarlyView.
Abstract Obesity affects billions of individuals world‐wide and brings with it greater susceptibility to secondary conditions, like that of type 2 diabetes mellitus (T2DM). One of the most effective therapeutic treatment strategies for obesity and T2DM is exercise, yet both populations present with severe exercise intolerance.
James P. Charles   +5 more
wiley   +1 more source

In silico modelling of multi‐electrode arrays for enhancing cardiac drug testing on hiPSC‐CM heterogeneous tissues

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the experimental and computational framework for investigating hiPSC‐CM electrophysiology with MEA systems. The MEA‐based model integrates experimental data with phenotype‐specific ionic models and tissue‐level heterogeneity.
Sofia Botti   +2 more
wiley   +1 more source

Co‐ingesting whey protein with dual‐source carbohydrate enhances amino acid availability without compromising post‐exercise liver glycogen resynthesis

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Graphical overview of the experimental study. The upper‐left panel presents the research question, and the bottom‐left panel provides a schematic overview of the experimental design. The right‐hand panel depicts repetitive spectral data obtained by magnetic resonance spectroscopy, liver glycogen content during the 5 h post ...
Sophie C. Hannon   +12 more
wiley   +1 more source

Resistance training tempo selectively modulates corticospinal and reticulospinal excitability in humans

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Three weeks of unilateral resistance training (RT) performed under metronome‐paced (MP‐RT) or self‐paced (SP‐RT) conditions increased strength (maximum voluntary force (MVF) and one‐repetition maximum (1RM)) but were accompanied by distinct neural adaptations.
Yonas Akalu   +7 more
wiley   +1 more source

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