Results 151 to 160 of about 31,775 (296)

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Mongo : adventures of trash

, 2011
BOTHA, Ted. Mongo : adventures of trash. Bloomsbury, 2004 Focusing on collectors of "mongo" — any discarded item that is rescued from the trash — this is a superbly crafted, eye-opening tour of the weird and fascinating world of people who really
SUD
core  

Integrating Untargeted GC-MS Metabolomics, GNPS Molecular Networking, and Machine Learning for Sugarcane Byproduct Valorization. [PDF]

ACS Omega
Pruksatrakul T, Sangsum C, Makmai S, Pongpamorn P, Paemanee A, Soontontaweesub S, Yoiprommarat S, Sittichok N, Suriyachai N, Pongchaiphol S, Raita M, Rungjang W, Bunyapaiboonsri T, Champreda V.   +13 more
europepmc   +1 more source

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source

White Trash Card

, 2003
Card promoting the White Trash exhibition at grunt gallery.

core  

Needle-shaped diatom frustules in food as a possible promoter of esophageal squamous cell carcinoma in coastal southeastern China: A pilot study. [PDF]

Int J Cancer
Wu H, Li Y, Ran L, Xia Z, Guo P, Deng S, Conway E, He Y, Zheng J, Zhu H, Tian L.   +10 more
europepmc   +1 more source

Stiffness‐Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG‐TNS4 Signaling

Advanced Science, EarlyView.
Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu, Jian Wan, Xue Zhang, Jiashuai Yan, Xi Chen, Xiaoqi Guan, Qianqian Ren, Tao Yang, Di Wu, Qingsong Guo, Yibing Guo, Yuhua Lu   +11 more
wiley   +1 more source

Characterization and intervention impacts on litter across public land types in Northern Idaho. [PDF]

Environ Monit Assess
Engels M, Panta M.
europepmc   +1 more source

Trashing

Trashing
Introduction I Trashing II Available remedies and sanctions III Attempts to improve remedies IV Trashing and freedom of expression reconsidered Conclusion Invited ...
openaire  

Decoding Gas Evolution Pathways and Interfacial Chemistry in Layered Oxide Cathodes for Safer Sodium‐Ion Batteries

Advanced Energy Materials, EarlyView.
Gas evolution behaviors of sodium layered oxide cathodes with varying compositions, cutoff voltages, dopants, and particle sizes/morphologies have been systematically investigated by online electrochemical mass spectrometry. The fundamental outgassing mechanisms of sodium‐based cathodes compared to lithium‐based cathodes have been elucidated.
Chen Liu, Zehao Cui, Arumugam Manthiram
wiley   +1 more source