Results 101 to 110 of about 3,051,315 (389)

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Complex Limb Injuries: Limb Salvage Versus Amputation—A Mini Review and Meta-Analysis

Advances in Orthopedics
Conclusion: Managing complex limb injuries effectively necessitates a comprehensive approach involving thorough assessment, multidisciplinary collaboration, and patient-centered care.
Athanasios Serlis, Panagiotis Sgardelis, Themistoklis Vampertzis, Konstantinos Rizavas, Panagiotis Poulios, Georgios Konstantopoulos   +5 more
doaj   +1 more source

Mothers who are Refugees: An analysis of trauma, social support, and parenting efficacy. [PDF]

, 2017
The following exploratory correlational study examined the relationships among trauma severity, social support, and parenting self-efficacy in a sample of mothers who are refugees living in Vermont.
Papka, Sophia Valeria
core   +1 more source

Blunt traumatic celiac artery avulsion managed with celiac artery ligation and open aorto-celiac bypass. [PDF]

, 2017
Traumatic celiac artery injuries are rare and highly lethal with reported mortality rates of 38-62%. The vast majority are caused by penetrating trauma with only 11 reported cases due to blunt trauma (Graham et al., 1978; Asensio et al., 2000, 2002 ...
Doben, Andrew R, Gross, Ronald I, Kravetz, Amanda, Kronick, Matthew D, Morris, Marvin E, Nahmias, Jeffry T   +5 more
core   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Shh Signaling from the Injured Lung Microenvironment Drives BMSCs Differentiation into Alveolar Type II Cells for Acute Lung Injury Treatment in Mice

Stem Cells International
Alveolar type II (AT2) cells are key effector cells for repairing damaged lungs. Direct differentiation into AT2 cells from bone marrow mesenchymal stem cells (BMSCs) is a promising approach to treating acute lung injury (ALI).
Mengyu Wu, Jing Liu, Shu Zhang, Yi Jian, Ling Guo, Huacai Zhang, Junwei Mi, Guoxin Qu, Yaojun Liu, Chu Gao, Qingli Cai, Dalin Wen, Di Liu, Jianhui Sun, Jianxin Jiang, Hong Huang   +15 more
doaj   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Development of a Short Trauma Screening Tool (STST) to Measure Child Trauma Symptoms: Establishing Content Validity [PDF]

, 2019
Purpose: The purpose of the study was to identify major symptom domain variables common to child trauma and create a prototype short trauma symptom screening tool (STST) intended for use in pediatric medical settings.
Allison, Jeroan J., MS MD, Forkey, Heather C., MD, Hirsh, Estelle, BA, Maguire, Laura L., RN MS PhD   +3 more
core   +2 more sources

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

Trauma no idoso [PDF]

Revista da Associação Médica Brasileira, 2002
The populational growth of the elderly, associated to a healthier and more active life, make this group of people more exposed to accidents. In some countries, trauma in the elderly is responsible for a high mortality rate, disproportionately higher than in the adults.
SOUZA, JOSÉ ANTONIO GOMES DE, IGLESIAS, ANTONIO CARLOS R.G.   +1 more
openaire   +5 more sources