Results 61 to 70 of about 897,839 (261)

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Bibliometric Analysis of Exosome Research in Spinal Cord Injury (2000–May 2024). Trends, Collaborations, and Emerging Insights

Drug Design, Development and Therapy
Zhihua Wang,1,* Hangchuan Bi,1,* Denghui Li,1 Wan Zhang,1 Chao Wang,1 Jianyi Yang,2 Xianglin Shen,1 Rongji Yan,1 Fei He,3 Hao Duan4 1Trauma Center, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, People’s ...
Wang Z, Bi H, Li D, Zhang W, Wang C, Yang J, Shen X, Yan R, He F, Duan H   +9 more
doaj  

Clinical patterns and predictors of trauma-related mortality over 13 years: a retrospective analysis from a Level 1 National trauma center

World Journal of Emergency Surgery
Background Qatar is one of six neighboring countries in the Gulf Cooperation Council region that form a political and economic alliance to foster multilateral cooperation.
Ayman El-Menyar, Sandro Rizoli, Ahammed Mekkodathil, Mohammad Asim, Sajid Atique, Abdel-Aziz Hammo, Hisham Jogol, Ahad Kanbar, Khalid Ahmed, Rafael Consunji, Husham Abdelrahman, Asmaa Al-Atey, Ahmad Kloub, Fernando Spencer Netto, Gustav Strandvik, Hassan Al-Thani   +15 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Trauma of the midface

Laryngo- rhino- otologie, 2015
GMS Current Topics in Otorhinolaryngology - Head and Neck Surgery; 14 ...
Kühnel, TS, Reichert, TE
openaire   +3 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

The impact of recreational marijuana commercialization on traumatic injury

Injury Epidemiology, 2019
Background The medical legalization of marijuana has been shown to result in an increased risk of motor vehicle injuries. In Colorado, commercialization of recreational marijuana (initiation of retail sales) occurred on January 1, 2014, resulting in the ...
Christine Chung, Kristin Salottolo, Allen Tanner, Matthew M. Carrick, Robert Madayag, Gina Berg, Mark Lieser, David Bar-Or   +7 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source