Results 181 to 190 of about 28,755 (262)

Panic buying in response to tariffs: a psychodynamic and psychoanalytic hypothesis for economic uncertainty. [PDF]

Front Public Health
Cooper M.
europepmc   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Cathepsin B - indicator for the release of lysosomal cyasteine proteinases in severe trauma and inflammation

, 1990
Assfalg-Machleidt, Irmgard, Jochum, Marianne, Nast-Kolb, Dieter, Siebeck, Matthias, Billing, Arend, Joka, Theo, Rothe, Gregor, Valet, Günter, Zauner, Rita, Scheuber, Heinz- Peter, Machleidt, Werner   +10 more
openaire   +2 more sources

Childhood trauma and psychological symptoms in young adults: examining the mediating role of vulnerable narcissism and the moderating role of psychological resilience. [PDF]

Front Behav Neurosci
Cebeci F.
europepmc   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Association of an integrated prehospital-to-in-hospital transfusion workflow with early outcomes in severe trauma requiring emergency transfusion: A single-center observational before-and-after study. [PDF]

J Int Med Res
Zhou H, Xu P, Chen Y, Chen W, Du C.
europepmc   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

[Effect of ionizing radiation on some immunobiological indices in sever mechanical trauma].

Ortopediia travmatologiia i protezirovanie, 1979
V P, Torbenko, L A, Ivanova
openaire   +1 more source

Associations between childhood trauma, intolerance of uncertainty, and symptom severity in obsessive-compulsive disorder. [PDF]

Front Psychiatry
Ünver H, Tatlı SZ, Öz T, Karakuş İH, Varlı MR, Demir A, Özcan Çetin K, Gündoğmuş İ.   +7 more
europepmc   +1 more source

Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics

Advanced Science, EarlyView.
This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li, Zhongguo Ren, Yiliang Lin, Xianfeng Xia, Tianlong Li, Kai Fung Chan, Philip Wai Yan Chiu, Wei Peng Yong, Mengmeng Sun   +8 more
wiley   +1 more source