Results 41 to 50 of about 1,395,609 (315)

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Traumatic axonal injury in the spinal cord evoked by traumatic brain injury [PDF]

, 2008
Although it is well known that traumatic brain injury (TBI) evokes traumatic axonal injury (TAI) within the brain, TBI-induced axonal damage in the spinal cord (SC) has been less extensively investigated.
Bukovics, Péter, Büki, András, Czeiter, Endre, Dóczi, Tamás, Kövesdi, Erzsébet, Lückl, János, Pál, József   +6 more
core   +1 more source

Traumatic amputations [PDF]

British Journal of Pain, 2013
Traumatic amputations remain one of the most emotionally disturbing wounds of conflict, as demonstrated by their frequent use in films to illustrate the horrors of war. Unfortunately, they remain common injuries, particularly following explosions, and, in addition, many survivors require primary amputation for unsalvageable injuries or to save their ...
Jon, Clasper, Arul, Ramasamy
openaire   +2 more sources

Hexaxial external fixator versus intramedullary nail in treating segmental tibial fractures: a retrospective study

BMC Surgery
Background It’s difficult to treat segmental tibial fractures (STFs), which are intricate injuries associated with significant soft tissue damage.
Zhiming Zhao, Hengsheng Shu, Peng Jia, Xu Chen, Feng Guo, Yabin Liu, Bowen Shi, Guoqi Ji, Chengkuo Cai, Yidong Shen   +9 more
doaj   +1 more source

Early outreach to survivors of the shootings in Norway on the 22nd of July 2011 [PDF]

European Journal of Psychotraumatology, 2014
Background: Under-treatment and unmet needs among survivors have been documented years after terror attacks. Improved early and proactive outreach strategies, including targeted interventions for individuals in need, are required.
Grete Dyb, Tine Jensen, Kristin Alve Glad, Egil Nygaard, Siri Thoresen   +4 more
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

From bone marrow mesenchymal stem cells to diseases: the crucial role of m6A methylation in orthopedics

Stem Cell Research & Therapy
Elucidating the molecular mechanisms underlying orthopedic diseases is crucial for guiding therapeutic strategies and developing innovative interventions.
Peng Li, Chu Zhang, Wen Yin, Mijia Tao, Zhipeng Niu, Yutao Cui, Dankai Wu, Feng Gao   +7 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Does posttraumatic stress predict frequency of general practitioner visits in parents of terrorism survivors? A longitudinal study

European Journal of Psychotraumatology, 2017
Background: Life threat to children may induce severe posttraumatic stress reactions (PTSR) in parents. Troubled mothers and fathers may turn to their general practitioner (GP) for help.
Jon Magnus Haga, Lise Eilin Stene, Siri Thoresen, Tore Wentzel-Larsen, Grete Dyb   +4 more
doaj   +1 more source

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source