Results 21 to 30 of about 71,132 (265)

In Situ Stress‐Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis

Advanced Science, EarlyView.
Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li, Hui Yuan, Honglei Xiao, Xiaodong Liu, Wenguo Cui   +4 more
wiley   +1 more source

Targeting NSUN2‐Mediated m5C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

Advanced Science, EarlyView.
NSUN2‐mediated m5C modification cooperates with ALYREF to stabilize and export IP3R3 mRNA, increasing IP3R3 expression and Ca2 + overload in chondrocytes. This signaling promotes mitochondrial dysfunction, NLRP3 inflammasome activation, and senescence, thereby accelerating osteoarthritis progression.
Guping Mao, Wei Li, Zhencan Lin, Zengfa Deng, Ming Li, Zongrui Jiang, Changzhao Li, Dianbo Long, Yan Kang   +8 more
wiley   +1 more source

Continued Root Formation after a Compound root Fracture in an Immature Permanent Incisor: A Case Report with a 2-year follow-up [PDF]

Journal of Dentistry
While traumatic injuries in the young permanent dentition are frequent, root fractures are relatively rare, particularly in immature teeth. This study reports the case of a 7-year-old boy who fell off a bicycle.
Maryam Enteghad, Safoora Sahebi, Saleh Hadian   +2 more
doaj   +1 more source

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

Advanced Science, EarlyView.
Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, an sonothermal‐responsive platform has been developed through constructing metal‐semiconductor interface on implants. Biofilm infection and deep vein thrombosis can be successfully treated by controllable ultrasound treatments.
Zhengdong Zhang, Pan Liu, Jie Lei, Shuchang Peng, Qiu Chen, Wei Guan, Yizhou Zhu, Gang Liu, Xiaobo Feng, Cao Yang, Lei Tan   +10 more
wiley   +1 more source

One‐Step Immobilized Phage Depolymerase Coatings for Catheter‐Related Bloodstream Infections

Advanced Science, EarlyView.
Catheter‐related bloodstream infections (CRBSI) caused by drug‐resistant Gram‐negative bacteria remain a major clinical challenge. Here, a polydopamine‐assisted depolymerase coating degrades bacterial capsules and restores serum‐mediated killing, effectively suppressing biofilms and reducing bacterial burden in vitro, ex vivo, and in vivo, presenting a
Lingkai Dong, Xingjin Li, Tao Hu, Qianqian Lu, Xiaoxu Zhang, Xi Chen, Yifan Luo, Zhong Zuo, Ronald Man Yeung Wong, Miao Xu, Tiancong Zhao, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Estimating in vivo midfoot and hindfoot joint locations using external skin markers

The Anatomical Record, EarlyView.
Abstract Musculoskeletal modeling offers a non‐invasive approach to analyze human movement, enabling estimation of forces that are difficult to measure experimentally. In musculoskeletal modeling, the human body is represented as rigid segments connected by joints.
Steven G. Lautzenheiser, Christine M. Harper   +1 more
wiley   +1 more source

Female Patients Exhibit a Narrower Glenoid Rim and Lower Bone Density in the Anteroinferior Quadrant Compared With Male Patients

Arthroscopy, EarlyView.
Purpose The purpose of this study was to evaluate sex‐based differences in glenoid rim morphology and bone density relevant to arthroscopic Bankart repair. Methods This retrospective study assessed differences in glenoid rim morphology between sexes in patients with shoulder instability and uninjured control subjects who underwent a magnetic resonance ...
Willem Geuskens, Haider Ali Lakdawala, Maïté Jaspers, Tom Doyle, Damir Rasidovic, Olivier Verborgt, Oisin Flanagan, Eoghan Hurley, Hannan Mullett   +8 more
wiley   +1 more source

Editorial Commentary: Machine Learning and 300,000 Simulations Confirm That Fragility Reflects the P Value, Not Trial Robustness: Taking Apart a Calculator to Reveal That 2 + 2 Equals 4

Arthroscopy, EarlyView.
Abstract The fragility index continues to be promoted as a measure of trial robustness despite evidence that it is little more than statistical significance in a different form. Two misconceptions have been particularly persistent throughout the fragility literature: first, that the fragility index can be directly compared with patients lost to follow ...
Jacob F. Oeding
wiley   +1 more source

A retrospective epidemiological study of paediatric femoral fractures

Swiss Medical Weekly, 2020
BACKGROUND Femoral fracture is a significant major trauma in children and adolescents, sometimes resulting in serious complications. This study aimed to determine the epidemiology of femoral fractures and to define associated injuries and ...
Raimonda Valaikaite, Anne Tabard-Fougère, Christina Steiger, Eleftheria Samara, Romain Dayer, Dimitri Ceroni   +5 more
doaj   +1 more source

From classroom to clinic: Evaluating the educational utility of two Thiel embalming methods

Anatomical Sciences Education, EarlyView.
Abstract Over three decades since its introduction, the Thiel embalming method remains a widely used and praised technique in anatomical education and clinical training. This study compared for the first time the Thiel original protocol (TO) and a Modified version (TM) across user groups—undergraduate medical students, student demonstrators in anatomy,
Veronica Antipova, Martin Siwetz, Simone Manhal, Niels Hammer   +3 more
wiley   +1 more source