Results 121 to 130 of about 3,430,257 (355)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Vaccine-associated Arthus reaction

Travel Medicine and Infectious Disease, 2023
Tanatorn Soravipukuntorn, MD, Anastasia Putri, MD, Kansuda Sarasaen, MSc, Phimphan Pisutsan, MD, Wasin Matsee, MD   +4 more
doaj   +1 more source

Impact of degrading permafrost on subsurface solute transport pathways and travel times [PDF]

, 2015
Andrew Frampton, Georgia Destouni
openalex   +1 more source

Promoting Rhema Tours and Travel's Holyland Tours Using a Marketing Booklet [PDF]

, 2017
Rhema Tours and Travel is a travel agency located in Jalan Jemursari 234A that specializes in Christian pilgrimage trips. It offers tours to Israel, Jordan, Egypt, and Europe. There were only a few people who know about Rhema Tours and Travel.
Ibrahim, J. I. (Jusuf), Puspita, N. (Natania)   +1 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Successful reduction of urinary catheter placement for correct and incorrect indications after introduction of a prevention bundle

Antimicrobial Stewardship & Healthcare Epidemiology
The prospective before-after quality improvement study was to assess bundle effectiveness to reduce urinary catheter days and prevent associated complications.
Michela Cipriani, Matthias Schlegel, Marianne Schwark-Bähler, Samuel Henz, Philipp Kohler, Werner C. Albrich   +5 more
doaj   +1 more source

HIV Vaccine Research: The Challenge and the Way Forward

Journal of Immunology Research, 2015
Human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) is a worldwide epidemic, with over 35 million people infected currently. Therefore, the development of a safe and effective HIV-1 vaccine is on top of the global health priority.
Hai-Bo Wang, Qiu-Hua Mo, Ze Yang
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Antimicrobial Resistance Trends, Resistance Mechanisms, and Antibiotic Consumption in COVID-19 Versus Non-COVID-19 Units: A Seven-Year Retrospective Cohort Study

Antibiotics
Background: The COVID-19 pandemic profoundly affected healthcare delivery and antibiotic prescribing, raising concerns about increasing antimicrobial resistance.
Stefan Porubcin, Alena Rovnakova, Ondrej Zahornacky, Pavol Jarcuska   +3 more
doaj   +1 more source