Results 121 to 130 of about 3,411,914 (309)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Successful reduction of urinary catheter placement for correct and incorrect indications after introduction of a prevention bundle

Antimicrobial Stewardship & Healthcare Epidemiology
The prospective before-after quality improvement study was to assess bundle effectiveness to reduce urinary catheter days and prevent associated complications.
Michela Cipriani, Matthias Schlegel, Marianne Schwark-Bähler, Samuel Henz, Philipp Kohler, Werner C. Albrich   +5 more
doaj   +1 more source

The poetics of travel through unravelling visual representations on postcards: A critical semiotics analysis

, 2021
Christina Bonarou
openalex   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Arriving on time: estimating travel time distributions on large-scale road networks

, 2013
Most optimal routing problems focus on minimizing travel time or distance traveled. Oftentimes, a more useful objective is to maximize the probability of on-time arrival, which requires statistical distributions of travel times, rather than just mean ...
Abbeel, Pieter, Bayen, Alexandre, Hofleitner, Aude, Hunter, Timothy, Kouvelas, Anastasios, Krichene, Walid, Reilly, Jack, Thai, Jerome   +7 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Hofstede’s Cultural Dimensions and Tourist Behaviors: A Review and Conceptual Framework [PDF]

This paper develops a conceptual framework for analyzing tourist behaviors and identifies three categories of behaviors based on the applications of Hofstede’s cultural dimensions and the processes underlying these influences.
Manrai, Ajay K., Manrai, Lalita A.
core  

Antimicrobial Resistance Trends, Resistance Mechanisms, and Antibiotic Consumption in COVID-19 Versus Non-COVID-19 Units: A Seven-Year Retrospective Cohort Study

Antibiotics
Background: The COVID-19 pandemic profoundly affected healthcare delivery and antibiotic prescribing, raising concerns about increasing antimicrobial resistance.
Stefan Porubcin, Alena Rovnakova, Ondrej Zahornacky, Pavol Jarcuska   +3 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Modeling the Influence of Land Use Developments on Transportation System Performance [PDF]

, 2019
The growth in the urban population has influenced urban sprawl, congestion, and subsequently, delays on the existing road infrastructure. New land use developments occur in every part of the city due to rapid economic development and to meet the demand ...
Manes, Ajinkya S., Pulugurtha, Srinivas S.   +1 more
core   +1 more source