Results 181 to 190 of about 308,592 (334)

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo   +9 more
wiley   +1 more source

Photonuclear Population of 229m,gTh in Th‐Doped Crystals Toward Nuclear Clock Development

open access: yesAdvanced Science, EarlyView.
This study demonstrates a novel photonuclear approach for producing the nuclear clock isomer 229mTh in thorium‐doped crystals, overcoming current supply limitations. Through cross‐section calculations and Monte Carlo simulations, we identify optimal crystal materials and irradiation conditions, achieving high signal‐to‐noise ratios.
Hao‐Yang Lan   +9 more
wiley   +1 more source

Charge‐Acoustic Phonon Coupling Determined Carrier Transport Properties in FAxMA1−xPbBr3 Perovskite Single Crystals

open access: yesAdvanced Science, EarlyView.
This study investigates acoustic phonon‑carrier coupling in FAxMA1−xPbBr3 single crystals using time‑domain Brillouin scattering. The results show that increasing the FA content in FAxMA1−xPbBr3 single crystal reduces both the elastic constant and the intrinsic carrier mobility governed by the acoustic phonon‑carrier coupling.
Wei Zhang   +7 more
wiley   +1 more source

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