Results 271 to 280 of about 35,714,339 (381)

Tumour-associated macrophages as treatment targets in oncology

Nature Reviews Clinical Oncology, 2017
A. Mantovani, F. Marchesi, A. Malesci, L. Laghi, P. Allavena   +4 more
semanticscholar   +1 more source

The Impact of Antiretroviral Therapy on Mortality in HIV Positive People during Tuberculosis Treatment: A Systematic Review and Meta-Analysis

, 2014
Anna Odone, Silvia Amadasi, Richard G. White, Ted Cohen, Alison D. Grant, Rein M G J Houben   +5 more
openalex   +2 more sources

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

A qualitative study of home- versus facility-based TB treatment for adolescents in Lima, Peru. [PDF]

Public Health Action
Roman-Sinche B, Doradea FM, Tintaya K, Lecca L, Chiang SS.   +4 more
europepmc   +1 more source

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.

New England Journal of Medicine, 1993
Diabetes Control, D. Nathan, S. Genuth, J. Lachin, P. Cleary, O. Crofford, M. Davis, L. Rand, C. Siebert   +8 more
semanticscholar   +1 more source

Influence of wood treatments on mechanical properties of wood–cement composites and of Populus Euroamericana wood fibers

, 2015
A. Quiroga, Victorio A. Marzocchi, Ignacio Rintoul   +2 more
openalex   +2 more sources

Rapamycin as a potential repurpose drug candidate for the treatment of COVID-19

, 2020
Amjad Husain, Siddappa N. Byrareddy
openalex   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The Impact of Retail-Sector Delivery of Artemether–Lumefantrine on Malaria Treatment of Children under Five in Kenya: A Cluster Randomized Controlled Trial

, 2011
Beth Kangwana, Sarah Kedenge, Abdisalan M. Noor, Victor A. Alegana, Andrew Nyandigisi, Jayesh Pandit, Greg Fegan, Jim Todd, Simon Brooker, Robert W. Snow, Catherine Goodman   +10 more
openalex   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source