Results 41 to 50 of about 10,545,887 (276)

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Sequentially Constrained Randomization in Preclinical Animal Studies

Function
Randomization is a key component to scientific inquiry as it facilitates unbiased estimation of treatment effects via balancing of measured and unmeasured prognostic variables across treatment groups.
Joseph Rigdon, Michael Walkup, David Amar, Matthew T Wheeler, Laurie J Goodyear, Sue Bodine, Karyn Esser, Denise Esserman, Michael E Miller   +8 more
doaj   +1 more source

Delayed Effect of Active Pressure Treatment on Endolymphatic Hydrops [PDF]

, 2017
OBJECTIVE: To identify eventual correlations between the effect of low-pressure treatment and endolymphatic hydrops in Ménière patients. MATERIAL AND METHODS: The study group consisted of subjects affected by definite Ménière disease (2015) and a severe
Atturo, Francesca, Barbara, Maurizio, Benincasa, ANNA TERESA, Covelli, Edoardo, Filippi, Chiara, Marrone, V., Monini, Simonetta, Tarentini, S., Vestri, Anna Rita, Volpini, Luigi   +9 more
core   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

PLGA nanoparticles loaded with recombinant antimicrobial protein PIP significantly improves the survival state and pathological damage caused by ETEC O8-induced sepsis in mice

Frontiers in Veterinary Science
IntroductionPeptide-based antimicrobial drugs are promising alternatives to antibiotics owing to their broad-spectrum bactericidal activity and unique pathogen membrane disruption mechanism.
Xian Li, Xian Li, Xian Li, Jianjie Li, Pengfei Qiu, Pengfei Qiu, Ying Zhang, Ying Zhang, Chunjiang Wang, Menglong Yue, Menglong Yue, Congshang Lei, Congshang Lei, Miao Yin, Miao Yin, Xuefeng Qi, Xuefeng Qi, Xiwen Chen   +17 more
doaj   +1 more source

The Effect of the Seawater Treatment on the Thermal and Morphological Properties of Oil Palm Empty Fruit Bunches Filled Poly (vinyl alcohol) [PDF]

, 2018
Since Malaysia and the surrounding of the South East Asian countries has developed a large amount of oil palm EFB as a waste product after being processed as a fuel or other application, thus oil palm EFB fibre has displayed great potential as ...
Aziz, S. A. (Siti), Sarjadi, M. S. (Mohd)   +1 more
core  

Depression and Treatment with Effective Herbs [PDF]

Current Pharmaceutical Design, 2019
Depression is a common psychiatric disease and one of the main causes of disability worldwide. In spite of certain developments in this field, chemical and synthetic drugs used for the treatment of depression disrupt the treatment process due to numerous side effects and high cost.
Fathinezhad, Z., Sewell, Robert, Lorigooini, Z., Rafieian-Kopaei, M.   +3 more
openaire   +2 more sources

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Treatment Effect Models with Strategic Interaction in Treatment Decisions

, 2020
This study considers treatment effect models in which others' treatment decisions can affect one's own treatment and outcome. Focusing on the case of two-player interactions, we formulate treatment decision behavior as a complete information game with ...
Hoshino, Tadao, Yanagi, Takahide
core  

Estimating the causal effect of a time-varying treatment on time-to-event using structural nested failure time models

, 2003
In this paper we review an approach to estimating the causal effect of a time-varying treatment on time to some event of interest. This approach is designed for the situation where the treatment may have been repeatedly adapted to patient characteristics,
Dawid A. P., Gill R. D., Lok J. J., Robins J. M., Robins J. M., Robins J. M., Robins J. M., Robins J. M., Robins J. M., Robins J. M., Rubin D. B., Van der Laan M. J., Van der Vaart A. W.   +12 more
core   +4 more sources