Results 201 to 210 of about 28,962,370 (286)

Arrhythmogenic Implications of Inflammatory Bowel Disease: Its Mechanisms and Treatment Effects. [PDF]

Cureus
Almasri ES, Siddiqui TW, Almasri RM, Abdulla G, Benoj AA, Pradeep G, Abu-Sa'da MO, Alaboud A, Fatayerji RN, Siddiqui RW.   +9 more
europepmc   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

A perspective on individualized treatment effects estimation from time-series health data. [PDF]

J Am Med Inform Assoc
Ghosheh GO, Gögl M, Zhu T.
europepmc   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Variance Estimation for Weighted Average Treatment Effects. [PDF]

Stat Biosci
Li H, Liu Y, Zhou Y, Liu J, Fu D, Matsouaka RA.   +5 more
europepmc   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Radiomics-based Differentiation of Recurrent Brain Metastases from Treatment Effects: A Multi-Institutional Comparative Study with Advanced Imaging. [PDF]

Radiol Imaging Cancer
Um H, Ismail M, Hill VB, Puri S, Yu JS, Lu L, Nayate AP, Higinbotham A, Rogers LR, Prasanna P, Bardhan M, Li C, Basree MM, Baschnagel AM, McMillan AB, Bhatia A, Ahluwalia MS, Veronesi MC, Tiwari P.   +18 more
europepmc   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Individualized treatment effects of CPAP on secondary cardiovascular outcomes in non-sleepy obstructive sleep apnea patients. [PDF]

Commun Med (Lond)
Cohen O, Al-Taie Z, Kundel V, Khan S, Devarakonda K, Le V, Robson PM, Anderson CS, Baumert M, Loffler K, McEvoy RD, Suárez-Fariñas M, Shah NA.   +12 more
europepmc   +1 more source