Circular RNAs: Unlocking new avenues in cardiometabolic disease management
Abstract figure legend In the heart circular RNAs (circRNAs) function as microRNA sponges, interact with proteins and can even undergo translation. Advances in bioinformatics now enable their identification through high‐throughput RNA sequencing, whereas computational analyses reveal differential expression in cardiac disease settings.
Kimberley M. Mellor +4 more
wiley +1 more source
Primary Genital HSV-2 Infection in a Resource-Limited Setting: Diagnostic Challenges and Clinical Implications. [PDF]
Maksud RO, Antuke NRPP, Qurrohman T.
europepmc +1 more source
Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò +18 more
wiley +1 more source
Delivering the future of immunotherapy: A state-of-the-art review of gene editing in immune cells with lipid nanoparticles. [PDF]
Ciganek I +6 more
europepmc +1 more source
ABSTRACT Introduction Artificial intelligence (AI) is a branch of technology enabling machines to emulate complex human skills; it can also entail problem‐solving using bioinspired methods. It is used for automating systematic literature reviews (SLR), that is, defining a clinical question, locating relevant literature, preliminary screening, study ...
Ana M. Barragán +5 more
wiley +1 more source
Systemic Delivery Strategies for Oncolytic Viruses: Advancing Targeted and Efficient Tumor Therapy. [PDF]
Xia Y, Li D, Yang K, Ou X.
europepmc +1 more source
The primary function of statins is to inhibit cholesterol synthesis, which contributes to their antidiabetic effects. However, the majority of the diabetic effects of statins are due to inhibition of isoprenoid synthesis. Atorvastatin, simvastatin and rosuvastatin possess the most pronounced diabetogenic properties. In contrast, lovastatin, fluvastatin,
Ali Nosrati Andevari, Mohsen Koolivand
wiley +1 more source
Nanoscale delivery systems for hepatocellular carcinoma: Functionalization, delivery strategies, and clinical challenges. [PDF]
Fu Z, Zheng B, Zhang J, Ruan J, Zheng D.
europepmc +1 more source
Early prediction of multiple organ failure for sepsis patients based on machine learning algorithms
Abstract In recent years, there has been a notable rise in sepsis incidence leading to more multiple organ failure and higher mortality. The lack of effective treatments for sepsis highlights the importance of early prediction in preventing multiple organ failure. This study aimed to develop a model for the early prediction of multiple organ failure in
Runnan He +11 more
wiley +1 more source

