Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Targeting treatment for optimal outcome [PDF]
Clinical Cardiology, 2000 Rapid assessment of patients presenting with acute chest pain is essential, in order to distinguish between those who have a life-threatening condition, such as myocardial infarction or unstable angina, and the substantial proportion who do not have an acute coronary syndrome.
openaire +3 more sources
Clinicopathological features and treatment outcome of oesophageal gastrointestinal stromal tumour (GIST): A large, retrospective multicenter European study [PDF]
, 2021 Mahmoud Mohammadi +18 more
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Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Occlusal outcome of orthodontic treatment. [PDF]
The Angle orthodontist, 1998 The aim of this study was to evaluate the overall quality of orthodontic treatment in a university clinic. Dental casts of 1870 patients (799 males and 1071 females) were evaluated at the pretreatment and posttreatment stages using the PAR index. The mean age was 13 +/- 4.1 years at the pretreatment stage and 16 +/- 3.9 years at the posttreatment stage.
Al Yami, E.A. +2 more
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Outcome conditioned treatment effects [PDF]
, 2013 This paper introduces average treatment effects conditional on the outcome variable in an endogenous setup where outcome Y , treatment X and instrument Z are continuous. These objects allow to refine well studied treatment effects like ATE and ATT in the case of continuous treatment (see Florens et al (2008)), by breaking them up according to the rank ...
Stefan Hoderlein, Yuya Sasaki
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Patient-reported outcomes with hypoglossal nerve stimulation for treatment of obstructive sleep apnea: a systematic review and meta-analysis [PDF]
, 2023 Marcel Braun +5 more
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Treatment of retroauricular keloids: Revision of cases treated at the ENT service of HC/UFPR
International Archives of Otorhinolaryngology, 2012 Introduction: Keloids are benign tumors arising from abnormal healing of the skin, and there are several procedures available for their treatment. Objective: The objective of this study was to evaluate the outcomes of patients undergoing ...
Bettina Carvalho +6 more
doaj +1 more source
Using expectation violation models to improve the outcome of psychological treatments
, 2022 Winfried Rief +8 more
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