Results 111 to 120 of about 2,817,627 (296)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

An overview of selected orthodontic treatment need indices [PDF]

open access: yes, 2011
Orthodontics is a fast developing science as well as the field of medicine in general. The attempt of this book is to propose new possibilities and new ways of thinking about Orthodontics beside the ones presented in established and outstanding ...
Borzabadi Farahani, Ali   +2 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Outcome of tuberculosis treatment and its predictors among HIV infected patients in southwest Ethiopia

open access: yes, 2017
Adane Teshome Kefale, Yeniewa Kerie Anagaw Department of Pharmacy, College of Health Sciences, Mizan-Tepi University, Mizan Aman, Ethiopia Background: Co-infection with HIV challenges treatment of tuberculosis (TB) and worsens the outcome.
Teshome Kefale A, Anagaw YK
core  

Outcome-specific network (treatment discontinuation due to adverse events, acute studies).

open access: yes, 2016
Outcome-specific network (treatment discontinuation due to adverse events, acute studies).
Stefanie Reken (2935926)   +4 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Compliance and outcome in treatment-resistant anorexia and bulimia: a retrospective study

open access: yes, 2001
Objectives - To investigate the extent to which compliance with treatment is related to outcome, and factors associated with compliance in a group of treatment-resistant eating-disordered in-patients.
Woodford, S.   +4 more
core  

Pregnancy outcome during haemodialysis: a case report [PDF]

open access: yes, 2009
Objective: Successful pregnancy outcome is an uncommon occurrence in women requiring chronic dialysis treatment. Methods: We reported the course and outcome of a case of pregnancy occurred in a woman affected by lupus erythematosus on chronic ...
Cosimo, Caterina, Franco, Ciro
core  

Treatment Outcomes

open access: yes
This chapter aims to provide guidelines on implementing treatment outcome measures (TOMs) in telemedicine. It outlines the definition and the ICF classification of TOMs and highlights the considerations for integrating TOMs in telemedicine. We identified the STEERING model, which guides toward the development of effective TM systems that have the ...
Suad J. Ghaben, Arimi Fitri Mat Ludin
openaire   +1 more source

Home - About - Disclaimer - Privacy