Results 151 to 160 of about 10,740,581 (285)

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Treatment outcome and prognostic indices in patients with hyperglycemic emergencies

, 2013
IU Ezeani,1 A Eregie,2 OS Ogedengbe21Department of Medicine, Federal Medical Centre, Umuahia, Abia State, Nigeria; 2Department of Medicine, University of Benin Teaching Hospital, Benin City, NigeriaObjective: The objective of this study is to assess the ...
Eregie A, Ezeani IU, Ogedengbe OS
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Editorial: Cholesteatoma surgery: treatment outcome and follow up. [PDF]

Front Surg
Thomeer H, Merkus P, Verhaert N, Lammers M.   +3 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Prediction of treatment outcome in nasopharyngeal carcinoma patients. [PDF]

BMC Cancer
Zhou G, Sijtsema NM, Li Y, Zhai T, Xi L, Li J, van der Schaaf A, van Dijk LV, Shi Y, Yang P, Langendijk JA.   +10 more
europepmc   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Correction: Analysis of treatment outcome variations in infantile epileptic spasms syndrome. [PDF]

Front Neurol
Gong X, Gan J, Wang X, Chen J, Rao X, Wang J, Shen Y, Zhang J.   +7 more
europepmc   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

The Final Report of the Substance Abuse Treatment Standards Task Force [2001?]

, 2001
"Approved by the Governor's Substance Abuse Prevention Council, November 30, 2001."The Final Report of the Substance Abuse Treatment Standards Task Force -- Introduction -- No Single Approach Will Work for Everyone -- Defining and Redefining Expectations
Kansas Substance Abuse Treatment Standards Task Force
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