Results 241 to 250 of about 11,281,730 (290)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Naming practice effects and inconsistencies relate to treatment outcome in people with aphasia. [PDF]

Neuropsychologia
Wilmskoetter J, Blackwood K, Kristinsson S, Walker G, Fridriksson J, Blackett DS, den Ouden DB, Rorden C, Hillis AE, Hickok G, Sayers S, Spell LA, Bonilha L.   +12 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Treatment outcome and its predictors among patients with status epilepticus in Africa: A systematic review and meta-analysis. [PDF]

Explor Res Clin Soc Pharm
Geremew GW, Wassie YA, Zeleke TK, Abebe RB, Tadesse G, Fentahun S, Anberbr SS, Ayele HS, Mengesha AK, Getachew D, Beyna AT, Worku MC, Bekalu AF, Tekle MT, Alemayehu TT.   +14 more
europepmc   +1 more source

Is sleep disturbance associated with treatment outcome among individuals with binge-spectrum eating disorders? A preliminary study. [PDF]

Eat Disord
Manasse SM, Lampe EW, D'Adamo L, Wetherall L, Juarascio AS.   +4 more
europepmc   +1 more source

Improving Treatment Outcome Prediction Beyond Self-Report: The Role of Drug-Biased Behavioral Measures. [PDF]

Biol Psychiatry Glob Open Sci
Zhang R.
europepmc   +1 more source

Treatment outcome and associated factors of pyogenic meningitis among children at Hawassa University comprehensive specialized hospital: a retrospective cross-sectional study. [PDF]

BMC Pediatr
Teklemariam AD, Hailu BD, Tesfaye AM, Woldegebriel TE, Mamo YA, Tegene BA, Bitewa DA.   +6 more
europepmc   +1 more source

Clinical Impact of a Germline CD19 Variant on Treatment Outcome After CAR-T Cell Therapy in Relapsed/Refractory Mantle Cell Lymphoma. [PDF]

Cancers (Basel)
Ruckstuhl SA, Seipel K, Shaforostova I, Bertschinger M, Bacher U, Pabst T.   +5 more
europepmc   +1 more source

Turbulent-like Dynamics Predict Treatment Outcome in Major Depressive Disorder

Ruhe H, Poirot M, Perl YS, Caan M, Marquering H, Deco G, Kringelbach M, Reneman L.   +7 more
europepmc   +1 more source