Results 301 to 310 of about 20,588,866 (381)

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

The association between patient engagement and treatment outcome in guided internet-delivered CBT for anxiety and depression. [PDF]

Front Psychol
Hammerfald K, Jahren HH, Solbakken OA.
europepmc   +1 more source

Cloning, expression, purification, and structural modeling of the Chandipura virus matrix protein

FEBS Open Bio, EarlyView.
This research protocol offers a guide for the cloning, expression, and purification of the Chandipura virus matrix protein using E. coli. It also includes a step‐by‐step procedure for cloning, expressing, and conducting fluorescence imaging of GFP‐fused Chandipura virus matrix protein in mammalian cell lines.
Mariana Grieben
wiley   +1 more source

Endodontic emergency patients' profile and treatment outcome - a prospective cohort study. [PDF]

BMC Oral Health
Haug SR, Røegh M, Fristad I.
europepmc   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Correction: Unraveling the Secrets Behind the Multidrug-Resistant Tuberculosis Treatment Outcome in Chronic Renal Failure Patients Requiring Hemodialysis: A Systematic Review. [PDF]

Cureus
Hernandez GN, Seffah K, Zaman MA, Awais N, Satnarine T, Haq A, Patel D, Gutlapalli SD, Ahmed A, Khan S.   +9 more
europepmc   +1 more source

Pretreatment relationship characteristics predict outcomes from an uncontrolled trial of intensive, multicouple group PTSD treatment.

Steffany J. Fredman, Yunying Le, Candice M. Monson, Jacqueline Mogle, Alexandra Macdonald, Tabatha H. Blount, Brittany N. Hall‐Clark, Brooke A. Fina, Katherine A. Dondanville, Jim Mintz, Brett T. Litz, Stacey Young‐McCaughan, Jeffrey S. Yarvis, Terence M. Keane, Alan L. Peterson   +14 more
openalex   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Gambling disorder and problematic pornography use: Does co-occurrence influence treatment outcome? [PDF]

J Behav Addict
Mestre-Bach G, Potenza MN, Granero R, Håkansson A, Gómez-Peña M, Perales I, Vicó À, Uríszar JC, Fernández-Aranda F, Sánchez I, Jiménez-Murcia S.   +10 more
europepmc   +1 more source