Results 261 to 270 of about 45,408,874 (353)

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Beyond Reconstruction: Return to Olympic Medal Performance Following Morphology-Informed and Criterion-Based Nonoperative Management of a Femoral-Sided Sherman Type II ACL Injury - A Case Report. [PDF]

Int J Sports Phys Ther
Gablac H, Rademacher C, Ehrenstein P, Düring M, Meyer LJ, Rühr C, Schellhammer U, Hoffmann M, Vonhoegen J, Behrendt P.   +9 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Concretizing the abstract: embodied learning as a pedagogical strategy for teaching measurement and evaluation. [PDF]

BMC Med Educ
Tutal Ö.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Effects of Acute <i>Ecklonia cava</i> Supplementation on Submaximal Cycling and Repeated-Sprint Performance in Trained Cyclists: A Randomised Double-Blind Placebo-Controlled Crossover Trial. [PDF]

Nutrients
Ali Y, Gurney T, Brouner J, Spendiff O.
europepmc   +1 more source

The Challenges of Hyperparameter Tuning for Accurate Causal Effect Estimation. [PDF]

Mach Learn
Machlanski D, Samothrakis S, Clarke P.
europepmc   +1 more source

Cognitive Impairment in Drug-Resistant Epilepsy: A Multidomain Systematic Review. [PDF]

Brain Sci
Bargielski M, Adamska-Patruno E, Krętowski A, Kochanowicz J, Kułakowska A, Chorąży M.   +5 more
europepmc   +1 more source

Contextual Semantic Pattern Recognition for Mental Health Monitoring Using ClinicalBERT Transformers. [PDF]

Brain Behav
Sun J.
europepmc   +1 more source

Hyperspectral Imaging and Interpretable Machine Learning for Bleaching-Level Identification and Treatment-Associated SO₂ Residue Estimation in Lanzhou Lily. [PDF]

Foods
Yan Y, Xie M, Liu J, Deng L, Qiu J, Yang S, Nie L, Li Z, Zhou H, Wang H.   +9 more
europepmc   +1 more source