Results 141 to 150 of about 10,762,797 (269)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Impact of Adherence to Guideline-Recommended Surgical Timing on Outcomes in Infective Endocarditis. [PDF]

J Clin Med
Pastor-Wulf D, Gonzalez-Manzanares R, Perea-Armijo J, Crespín-Crespín M, López-Aguilera J, Pan M, Castillo JC, Anguita M.   +7 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The National Treatment Purchase Fund: treating people faster.

, 2006
The National Treatment Purchase Fund (NTPF) was set up by the Government to treat patients like you, who have been longest on public hospital waiting lists for an operation.
National Treatment Purchase Fund
core  

Priority-setting assessment components.

The figure shows three main components of a priority-setting assessment: process, function, and outcome. In a basic form, a single process component leads to input for the function which produces an output as the final outcome of the priority-setting ...
Charlotte M. W. Gaasterland (18319804), Michiel S. Oerbekke (8724477), Maarten J. van der Laan (5676032), Lotty Hooft (138315)   +3 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Aligning Priorities of Surgeons and Patients Regarding Obesity and Joint Replacement: Recommendations of the Advisory Committee Codesigning Solutions Regarding Obesity and Arthroplasty Consensus Working Group. [PDF]

Arthroplast Today
Godziuk K, Rubinett L, Van't Haaff C, Bohm E, Chaudhry H, Cohen-Rosenblum A, Ricciardi B, Giori NJ.   +7 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

4155 Using the Patient Generated Index (PGI) to elicit quality of life priorities in patients following curative treatment for colorectal cancer: experience from two lifestyle intervention development studies

European Journal of Cancer Supplements, 2009
M. Wells, A.S. Anderson, S. Caswell, K. Craig, J. Connaghan, S. MacAskill, R.J.C. Steele   +6 more
openaire   +1 more source

Molecular Diagnostics for WHO Priority Bacterial Pathogens: A Bibliometric Mapping of Diagnostic Platforms, Resistance Markers, and Antimicrobial Resistance Research Trends. [PDF]

Microbiologyopen
Ünlü S.
europepmc   +1 more source