Results 171 to 180 of about 123,574 (243)

Indigenous inoculant dampens the impact of remediation of heavy metal polluted soil on arbuscular mycorrhizal fungal communities. [PDF]

Mycorrhiza
Šibanc N, Clark DR, Suhadolc M, Leštan D, Dumbrell AJ, Maček I.   +5 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Recent HIV infection among women and men enrolling to care in urban clinics in Ethiopia. [PDF]

BMC Infect Dis
Abdulahi IJ, Björkman P, Sasinovich S, Alemayehu DH, Arimide D, Mihret A, Abdissa A, Mulu A, Medstrand P, Reepalu A.   +9 more
europepmc   +1 more source

[A new index of priorities for orthodontic treatment. 1: Description].

Revista cubana de estomatologia, 1983
openaire   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Out-of-Pocket Costs and Antihypertensive Medication Use Among Veterans: A Natural Experiment. [PDF]

J Am Heart Assoc
Zheutlin AR, Chaitoff A, Addo D, Jacobs JA, Derington CG, Stulberg EL, Glynn PA, Modenesi B, Cohen JB, Bress AP.   +9 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Between Achievement and Challenge: Examining China's Tuberculosis Control Pathway and Future Directions from a Global Perspective. [PDF]

China CDC Wkly
Zhang Y, Sun D, Diao L.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Strategic Delay and Bargaining Over Public Insurance Coverage for Drugs in Australia. [PDF]

Health Econ
Li JJ, Harris A.
europepmc   +1 more source