Results 171 to 180 of about 14,958,381 (308)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Very low protein plus ketoacid analogs of essential aminoacids do not confirm superiority of a low protein diet to retard chronic kidney disease progression

Kidney Research and Clinical Practice, 2019
Piergiorgio Bolasco
doaj   +1 more source

Insufficient weight loss after bariatric surgery and its predictors: Tehran Obesity Treatment Study (TOTS). [PDF]

Langenbecks Arch Surg
Almasi MH, Barzin M, Mahdavi M, Khalaj A, Ebrahimi D, Valizadeh M, Hosseinpanah F.   +6 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Steerable versus Conventional flexible and navigable suction ureteral access sheath (FANS) flexible Ureteroscopy for Lower Pole stones Treatment: study protocol for a multicentre, randomised superiority trial (SCULPT trial). [PDF]

BMJ Open
Yuen SKK, Liu S, Gauhar V, Mai H, He W, Hu H, Ke C, Dai Y, Shan L, Jiang Y, Yuan J, Cao Z, Zuo L, Yang C, Bai B, Bi X, Zhao H, Xi M, Ding N, Deng S, Tang S, Zeng J, Du J, Wu W, Ma J, Zhong W, Zhao Z, Liu Y, de la Rosette J, Zeng G, Zhu W.   +30 more
europepmc   +1 more source

Refractive Growth of the Crystalline Lens in the Infant Aphakia Treatment Study. [PDF]

Ophthalmol Sci, 2022
McClatchey TS, Lambert SR, Morrison DG, Kruger SJ, Wilson LB, McClatchey SK, Infant Aphakia Treatment Study Group.   +6 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Prevalence of ADHD in a Sample of Heroin Addicts Receiving Agonist Treatment-Study Conducted in a Public Addiction Service. [PDF]

Int J Environ Res Public Health, 2023
Rocco P.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Legacy of the Tehran Obesity Treatment Study: Findings from 10 Years Bariatric Surgery Survey. [PDF]

Int J Endocrinol Metab
Abiri B, Heidari Almasi M, Hosseinpanah F, Molavizadeh D, Khalaj A, Mahdavi M, Valizadeh M, Barzin M.   +7 more
europepmc   +1 more source