Results 51 to 60 of about 1,770,995 (274)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Tracing ancient solar cycles with tree rings and radiocarbon in the first millennium BCE
Nature CommunicationsThe Sun drives Earth’s energy systems, influencing weather, ocean currents, and agricultural productivity. Understanding solar variability is critical, but direct observations are limited to 400 years of sunspot records.
Nicolas Brehm +7 more
doaj +1 more source
Frontiers in Forests and Global Change, 2020 The impact of ecological and climatological factors on individual organisms over time and space is inherently complex and creates substantial uncertainty about how climate change will influence the global biosphere. To understand some of this complexity,
Neil Pederson +9 more
doaj +1 more source
Unprecedented acceleration of winter discharge of Upper Yenisei River inferred from tree rings
Environmental Research Letters, 2021 The Yenisei River is the largest contributor of freshwater and energy fluxes among all rivers draining to the Arctic Ocean. Modeling long-term variability of Eurasian runoff to the Arctic Ocean is complicated by the considerable variability of river ...
Irina P Panyushkina +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Publisher Correction: Rapid 14C excursion at 3372-3371 BCE not observed at two different locations
Nature Communications, 2021 A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-21647 ...
A. J. Timothy Jull +9 more
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Apportionment of Chemical Components and Sources of PM2.5 in Shihezi City of Xinjiang, China
Atmosphere, 2023 In order to reveal the pollution characteristics and sources of PM2.5, in this study, we collected PM2.5 filter membrane samples in Shihezi continuously from December 2020 to January 2021, and analyzed 10 kinds of water-soluble inorganic ions (WSIIs) and
Yuting Zhong +5 more
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source