Results 161 to 170 of about 244 (197)

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Editorial: Exploring wood structure and tree-ring dynamics in ecological research

Frontiers in Plant Science
Alma Piermattei, Alma Piermattei, Ignacio García-González, Fabio Gennaretti, Marta Górska, Luis Silva, Alan Crivellaro, Alan Crivellaro   +7 more
doaj   +1 more source

A Pentaradial and Bilateral Combined Photoreception System in the Sea Cucumber is Mediated by a Blue Light‐Sensitive R‐Opsin

Advanced Science, EarlyView.
The sea cucumber Holothuria leucospilota detects blue and adjacent wavelengths of light via an r‐opsin with a maximum absorption at 459 nm. In the oral tentacles, papillae, and tube feet, distinct light‐sensing structures with specialized morphologies are formed, constituting a unique pentaradial and bilateral combined photoreception system.
Jiasheng Huang, Chunhua Ren, Zhou Qin, Yimeng Cui, Bingbing Zhang, Peng Luo, Xuan Wang, Yaoqi Xie, Xin Zhang, Aifen Yan, Yang Zhang, Dingding Fan, Yang Liu, Wenjie Pan, Xiao Jiang, Lihong Yuan, Haipeng Qin, David M. Irwin, Chaoqun Hu, Yang Liu, Ting Chen   +20 more
wiley   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

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Fennoscandian tree-ring anatomy shows a warmer modern than medieval climate

Nature, 2023
Earth system models and various climate proxy sources indicate global warming is unprecedented during at least the Common Era1. However, tree-ring proxies often estimate temperatures during the Medieval Climate Anomaly (950-1250 CE) that are similar to, or exceed, those recorded for the past century2,3, in contrast to simulation experiments at regional
Kristina Seftigen, Björn Gunnarson, Hugues Goosse   +2 more
exaly   +4 more sources

Exploring wood anatomy, density and chemistry profiles to understand the tree-ring formation in Amazonian tree species

Dendrochronologia, 2022
Fil: Santini, Luiz.
Andrea Hevia Cabal, Sánchez-Salguero Raúl, Mario Tomazello-Filho   +2 more
exaly   +3 more sources

Tree ring anatomy indices of Pinus tabuliformis revealed the shifted dominant climate factor influencing potential hydraulic function in western Qinling Mountains

Dendrochronologia, 2021
Abstract Trees can adjust xylem anatomical structure related with potential hydraulic functions to cope with climate variability. We therefore need a better understanding of how climate variability constrains wood anatomy and tree radial growth. Pinus tabuliformis dominates natural forests and plantations over the western Qinling Mountains, which is ...
Aritsara Amy Ny Aina, Qiang Qiang Lu, Xiaoyu Xing   +2 more
exaly   +2 more sources

Relationship between wood anatomy, tree-ring widths and wood density of Pinus sylvestris L. and climate at high latitudes in northern Sweden

Dendrochronologia, 2014
In this study, wood anatomy, tree-ring width and wood density of Pinus sylvestris at the northern timberline in Fennoscandia were used to identify relationships among the parameters and to screen them for their climatic signals. Furthermore we investigated the influence of the juvenile wood section for all parameters developed. The measurements of wood
Gerhard Helle, Carola Pritzkow, Håkan Grudd   +2 more
exaly   +4 more sources

Response of floodplain pedunculate oak (Quercus robur L.) tree-ring width and vessel anatomy to climatic trends and extreme hydroclimatic events

Forest Ecology and Management, 2016
Abstract Increasing temperatures and recent changes in runoff regimes observed in Central Europe might alter the growth and relative water uptake of floodplain trees. To predict responses of floodplain forests to climate change, it is necessary to determine the climatic controls over tree growth and vessel anatomy.
Václav Treml, Jan Tumajer
exaly   +2 more sources

Is tree-ring anatomy the key? searching for an optimal dendrogeomorphic approach to distinguish shallow creep and true slide movements

Catena, 2023
Karel Silhan
exaly   +2 more sources