Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh +11 more
wiley +1 more source
Assessment of Genetic Diversity and Differentiation in <i>Triadica cochinchinensis</i> Populations Using SSR Markers. [PDF]
Zhou P, Zhou Q, Zhang C, Xu M, Li Y.
europepmc +1 more source
3D Chromatin Architecture Provides Insights Into Leaf Trait Variation Among Pear Species
ABSTRACT Three‐dimensional (3D) chromatin architecture plays a fundamental role in eukaryotic gene regulations, its functional significance in perennial fruit trees remains poorly characterized despite extensive applications in crop genomics. Here, we developed high‐resolution (∼5 kb) Hi‐C maps of Pyrus and compared 3D genomic architecture of three ...
Yueyuan Liu +11 more
wiley +1 more source
Biochemical, Mineral, and Morphological Properties of Indian Tamarind (<i>Tamarindus indica</i> L.). [PDF]
Mishra DS +10 more
europepmc +1 more source
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska +14 more
wiley +1 more source
Genetic Diversity and Core Collection Construction of <i>Cymbidium ensifolium</i> var. susin. [PDF]
Zhang L +11 more
europepmc +1 more source
Global Nitrogen Deposition Promotes Carbon Sink Formation in Terrestrial Ecosystems
Nitrogen deposition alleviates ecosystem N limitation and enhances carbon sinks. Using 829 observations, we show 36% of deposited N is retained globally (39.15 Tg N yr−1), with distinct NHx and NOy contributions. This retention drives a terrestrial C sink of 0.88 Pg C yr−1 (25.48%), highlighting the importance of pool‐specific C:N stoichiometry ...
Lei Li +6 more
wiley +1 more source
Genetic Variation and Phylogenetic Analysis of Indonesian Sugarcane (<i>Saccharum officinarum</i> L.) based on Internal Transcribed Spacer (ITS-nrDNA). [PDF]
Aristya GR +5 more
europepmc +1 more source
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu +18 more
wiley +1 more source

