Results 61 to 70 of about 101,371 (270)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Efficient Non-Binary Gene Tree Resolution with Weighted Reconciliation Cost [PDF]

, 2016
Polytomies in gene trees are multifurcated nodes corresponding to unresolved parts of the tree, usually due to insufficient differentiation between sequences of homologous gene copies.
El-Mabrouk, Nadia, Lafond, Manuel, Noutahi, Emmanuel   +2 more
core   +1 more source

Reconciliation feasibility in the presence of gene duplication, loss, and coalescence with multiple individuals per species

BMC Bioinformatics, 2017
Background In phylogenetics, we often seek to reconcile gene trees with species trees within the framework of an evolutionary model. While the most popular models for eukaryotic species allow for only gene duplication and gene loss or only multispecies ...
Jennifer Rogers, Andrew Fishberg, Nora Youngs, Yi-Chieh Wu   +3 more
doaj   +1 more source

Multi-faceted analysis provides little evidence for recurrent whole-genome duplications during hexapod evolution

BMC Biology, 2020
Background Gene duplication events play an important role in the evolution and adaptation of organisms. Duplicated genes can arise through different mechanisms, including whole-genome duplications (WGDs).
Dick Roelofs, Arthur Zwaenepoel, Tom Sistermans, Joey Nap, Andries A. Kampfraath, Yves Van de Peer, Jacintha Ellers, Ken Kraaijeveld   +7 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Predicting the Evolution of Syntenies—An Algorithmic Review

Algorithms, 2021
Syntenies are genomic segments of consecutive genes identified by a certain conservation in gene content and order. The notion of conservation may vary from one definition to another, the more constrained requiring identical gene contents and gene orders,
Nadia El-Mabrouk
doaj   +1 more source

Effectiveness and cost effectiveness of pharmacist input at the ward level: a systematic review and meta-analysis [PDF]

, 2018
Background Pharmacists play important role in ensuring timely care delivery at the ward level. The optimal level of pharmacist input, however, is not clearly defined.
Aag, Al-Rashed, Baqir, Bates, Bladh, Bourne, Claus, Dalia M. Dawoud, David Wonderling, Dawoud, Dunn, Eggink, Farley, Farris, Fertleman, Gallagher, Gammie, Gandhi, Ghatnekar, Gillespie, Graabaek, Group GW, Hepler, Jennifer Hill, Joanna Ashe, Julian Bion, Karnon, Kaushal, Khalil, Klopotowska, Kucukarslan, Landeiro, Law, Lind, Lisby, Maria Smyth, Mihir Varia, National Clinical Guideline Centre, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, Nester, Nickerson, OECD, Olalekan, Perez, Philip Dyer, Scullin, Shen, Slawomirski, Spinewine, Thomas Strong, Tong, Touchette, Wallerstedt, Zegers, Zhao, Zhao   +57 more
core   +3 more sources

Inferring duplication episodes from unrooted gene trees

BMC Genomics, 2018
Background One of evolutionary molecular biology fundamental issues is to discover genomic duplication events and their correspondence to the species tree.
Jarosław Paszek, Paweł Górecki
doaj   +1 more source

Space of Gene/Species Trees Reconciliations and Parsimonious Models [PDF]

Journal of Computational Biology, 2009
We describe algorithms to study the space of all possible reconciliations between a gene tree and a species tree, that is counting the size of this space, uniformly generate a random reconciliation, and exploring this space in optimal time using combinatorial operators.
Jean-Philippe, Doyon, Cedric, Chauve, Sylvie, Hamel   +2 more
openaire   +2 more sources