Results 71 to 80 of about 101,371 (270)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Gene tree reconciliation: new developments in Bayesian concordance analysis with BUCKy [PDF]

, 2010
When phylogenetic trees inferred from different genes are incongruent, several methods are available to reconcile gene trees and extract the shared phylogenetic information from the sequence data. Bayesian Concordance Analysis, implemented in BUCKy, aims
Bret R. Larget, Cé, Colin N. Dewey, Satish K. Kotha   +3 more
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Extracting few representative reconciliations with Host-Switches (Extended Abstract) [PDF]

, 2017
Phylogenetic tree reconciliation is the approach commonly used to in- vestigate the coevolution of sets of organisms such as hosts and symbionts. Given a phylogenetic tree for each such set, respectively denoted by H and S, together with a mapping φ of ...
Calamoneri, T., Gastaldello, M., Sagot, M. -F.   +2 more
core  

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

iGTP: A software package for large-scale gene tree parsimony analysis

BMC Bioinformatics, 2010
Background The ever-increasing wealth of genomic sequence information provides an unprecedented opportunity for large-scale phylogenetic analysis. However, species phylogeny inference is obfuscated by incongruence among gene trees due to evolutionary ...
Fernández-Baca David, Wehe André, Bansal Mukul S, Chaudhary Ruchi, Eulenstein Oliver   +4 more
doaj   +1 more source

Evolution of genes and repeats in the Nimrod superfamily [PDF]

, 2008
The recently identified Nimrod superfamily is characterized by the presence of a special type of EGF repeat, the NIM repeat, located right after a typical CCXGY/W amino acid motif.
Andrade, B. Sipos, Bork, Bork, Callebaut, Chen, D. Hultmark, Do, Doliana, E. Kurucz, Edgar, Evans, Finn, Guindon, Holt, Huelsenbeck, Hughes, I. Ando, J. Zsamboki, Ju, K. Somogyi, Kumar, Kumar, Kurucz, Liao, Mangahas, McAllister, Morgenstern, Nei, Nei, Nei, Nei, Nishikawa, Notredame, Ota, Parmley, Posada, Quesada, Redelings, Russo, Schuster-B  ckler, Simmons, Stajich, Strimmer, Swanson, Swidan, Thompson, Xia, Z. Penzes, Zdobnov, Zhang, Zou   +51 more
core   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Gene trees and species trees: irreconcilable differences

BMC Bioinformatics, 2012
Background Reconciliation is the classical method for inferring a duplication and loss history from a set of extant genes. It is based upon the notion of embedding the gene tree into the species tree, the incongruence between the two indicating evidence ...
Swenson Krister M, El-Mabrouk Nadia
doaj   +1 more source

Telework in Times of Crisis: Redesign as Imperative for Performance and Wellbeing at Work

Revista Psicologia, 2023
The present study aimed to characterize the impact of compulsory telework on the performance and wellbeing of teleworkers regarding psychological needs and work redesign.
Lilia Vianna, Elisa Maria Barbosa de Amorim Ribeiro, Luciana Mourão, Hugo Sandall   +3 more
doaj   +1 more source