Results 271 to 280 of about 2,110,315 (345)

Machine learning estimation and optimization for evaluation of pharmaceutical solubility in supercritical carbon dioxide for improvement of drug efficacy. [PDF]

Sci Rep
Alotaibi HF, Hsu CY, Sead FF, Yadav A, Jyothi S R, Mishra S, Purohit B, Ashirova A, Yaxshimuratov M, Chauhan AS.   +9 more
europepmc   +1 more source

The fruit manual : a guide to the fruits and fruit trees of Great Britain

, 1884
Robert Hogg
openalex   +2 more sources

First‐Principles Structure–Activity Relationship Insights Into Phenolic Scaffolds: QSAR Modeling and Drug‐Likeness Screening

Advanced Theory and Simulations, EarlyView.
Integrated machine learning framework for phenolic derivatives: classification (toxicity) and regression (logP) models identify top drug‐like compounds. Random Forest outperformed for toxicity, while Linear Regression best predicted logP. A weighted scoring approach prioritized five safe, lipophilicity‐optimized candidates, supporting rational ...
Houria Nacer, Sridhar Priyankha, Gopal Hema, Anouar Zerouali, Hamza Haddag, Muneerah Mogren Al Mogren, Muthuramalingam Prakash, Majdi Hochlaf   +7 more
wiley   +1 more source

Molecular Characterization, Identification of the Volatile Organic Compounds by GC-MS, and Assessment of the Cytotoxic Activity of Leaves of <i>Pimenta dioica</i> L. Merrill Trees from Mexico. [PDF]

Metabolites
Montalvo-López I, García-Mateos MDR, Martínez-Solís J, Soto-Hernández RM, Ybarra-Moncada MC.   +4 more
europepmc   +1 more source

An account of several curious observations and experiments, concerning the growth of trees; made by Thomas Brotherton, of Hey, in the County of Lancaster, Esq. Brought in and read before the R. S. by R. H. Fellow of the said Society [PDF]

Thomas Brotherton, Robert Hooke
openalex   +1 more source

ST6GAL1‐Mediated Sialylation Stabilizes PD‐L1 and Drives Immunosuppressive Tumor Microenvironment in Colorectal Cancer

Advanced Science, EarlyView.
ST6GAL1 plays a critical role in tumor progression and immune regulation in colorectal cancer (CRC). Its depletion significantly suppresses the malignant phenotype of CRC cells and enhances the efficacy of anti‐PD‐L1 therapy. High ST6GAL1 expression promotes an immune‐activated tumor microenvironment (TME), characterized by increased infiltration of ...
Ximo Xu, Jingyi Liu, Wei Qin, Chengsheng Ding, Zhenghao Cai, Duohuo Shu, Hao Zhong, Yanyan Hu, Mengqin Yu, Leqi Zhou, Jianwen Li, Minhua Zheng, Bin Li, Sen Zhang, Xiao Yang, Bo Feng   +15 more
wiley   +1 more source

Ionomic Signatures of Olive Trees Affected by Quick Decline Syndrome. [PDF]

Plants (Basel)
Balestra GM, Giordani M, Coppa E, Schiavi D, Astolfi S.   +4 more
europepmc   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Distinguishing Phylogenetic Level-2 Networks with Quartets and Inter-Taxon Quartet Distances. [PDF]

Bull Math Biol
Holtgrefe N, Allman ES, Baños H, van Iersel L, Moulton V, Rhodes JA, Wicke K.   +6 more
europepmc   +1 more source