Results 271 to 280 of about 2,687,568 (346)

THE GUANGO, OR RAIN TREE

open access: hybrid, 1905

openalex   +1 more source

Integrating Dense Genotyping with High‐Throughput Phenotyping Empowers the Genetic Dissection of Berry Quality and Resilience Traits in Grapevine

open access: yesAdvanced Science, EarlyView.
Researchers develop advanced tools to study grapevine traits like berry quality and stress resilience. A 200K SNP array and high‐throughput phenotyping enable the identification of loci linked to berry shape, sugar content, acidity, and cold tolerance. Functional validation of genes such as NAC08 reveals roles in cold tolerance.
Yuyu Zhang   +11 more
wiley   +1 more source

Gut Microbiota Colonization in Early Life Influences Susceptibility to Adulthood Hepatic Lipid Accumulation in High‐Fat‐Diet‐Fed Mice

open access: yesAdvanced Science, EarlyView.
This study indicates that perinatal antibiotic exposure elevates susceptibility to high‐fat‐diet‐induced hepatic lipid accumulation via disrupting early‐life gut microbiota colonization. The decreased Lactobacillus colonization inhibits primary‐to‐secondary bile acid conversion, lowering secondary bile acids, enhancing adulthood intestinal lipid ...
Yan‐Yan Zhu   +11 more
wiley   +1 more source

Adaptation to Leaf Traits of Individual Trees in a Forest Appears Rare in Caterpillars. [PDF]

open access: yesEcol Evol
Molleman F   +4 more
europepmc   +1 more source

Machine Learning‐Enhanced Optimization for High‐Throughput Precision in Cellular Droplet Bioprinting

open access: yesAdvanced Science, EarlyView.
A high‐throughput droplet‐based cellular bioprinting platform enhanced with machine learning optimizes five key printing parameters—bioink viscosity, nozzle size, printing time, printing pressure, and cell concentration—to enable accurate prediction of droplet size.
Jaemyung Shin   +7 more
wiley   +1 more source

Lactylation‐Driven NUPR1 Promotes Immunosuppression of Tumor‐Infiltrating Macrophages in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
Cai et al. report that tumor‐derived lactate induces NUPR1 expression via H3K18 lactylation, which can promote the pro‐tumor M2 macrophage polarization through ERK and JNK signaling pathways. Treatment with NUPR1 selective inhibitor sensitizes synergizes with anti‐PD‐1 therapy in murine preclinical models.
Jialiang Cai   +12 more
wiley   +1 more source

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