Results 41 to 50 of about 919,373 (313)

Logistic model trees

, 2005
Tree induction methods and linear models are popular techniques for supervised learning tasks, both for the prediction of nominal classes and numeric values.
Hall, Mark A., Landwehr, Niels, Frank, Eibe   +2 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

High-throughput sequencing-based assembly of chloroplast genomes of five pine tree species

Mitochondrial DNA. Part B. Resources, 2020
Pinus plants are the largest existing group of gymnosperms and one of the most highly differentiated taxa. Due to its huge ecological, economic, and scientific value, the genetic diversity and the relationship between the intraspecific evolution of Pinus
Qunfeng Luo, Zhangqi Yang, Yuanheng Feng, Jie Jia, Jianhui Tan, Peidong Yan   +5 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Height-diameter allometry of tropical forest trees [PDF]

, 2010
Tropical tree height-diameter (H:D) relationships may vary by forest type and region making large-scale estimates of above-ground biomass subject to bias if they ignore these differences in stem allometry.
Banin, Lindsay, L. White, F. Schrodt, Feldpausch, T.R., Iida, Y, Affum-Baffoe, K., K. S.-H. Peh, Wöll, H., B. H. Marimon-Junior, Patino, S, Fyllas, N M, King, D.A., O. L. Phillips, De Camargo, P, Lopez-Gonzalez, G, Woll, H, B. S. Marimon, Taedoumg, H E, de Camargo, P., Metcalfe, D.J., Sonke, B, Reitsma, J. M., Marimon-Junior, B H, Baker, Timothy R, S. Tan, Kassim, A R, Feldpausch, T. R., Salim, K A, Marshall, A. R., Peh, Kelvin S.-H., Drescher, M, Brondizio, E.S., Nilus, R., Taedoumg, H.E., E. F. Moran, Lopez-Gonzalez, G., D. J. Metcalfe, Phillips, O L, Keller, M, Nogueira, E. M., Keller, M., M. Palace, Nogueira, E.M., Higuchi, N., Quesada, Carlos A, Phillips, O.L., Baker, T R, Djagbletey, G., Franca, M. B., Phillips, Oliver L, Raventos, M. T., Berry, Nicholas J, Quesada, CA, White, L, Y. Iida, E. M. Nogueira, Domingues, T.F., K. A. Salim, Taedoumg, H. E., Quesada, C A, Hunter, M.O., Marshall, Andrew R, Camargo, P., de, Lenza, E., Hunter, M. O., E. T. A. Mitchard, Lovett, J C, G. Lopez-Gonzalez, E. S. Brondizio, Berry, N J, Arets, E.J.M.M., Baker, T.R., Lewis, S L, Tan, S., Hunter, M O, K. Abu Silam, Marshall, A.R., A. Hladik, Marimon-Junior, B.H., Woell, H., Brondizio, E. S., King, D A, P. M. Fearnside, Moran, E.F., Arets, E J M M, Phillips, OL, Abu Salim, K., S. Patiño, K. Affum-Baffoe, Higuchi, N, Marimon, B S, Affum-Baffoe, Kofi, Peh, K.S-H., N. M. Fyllas, Fyllas, N. M., Lovett, J. C., Lewis, SL, S. L. Lewis, Fyllas, N.M., Phillips, O. L., Lloyd, J, White, Lee, Lovett, Jonathan Cranidge, Schrodt, F, Djagbletey, Gloria, Salim, K.A., M. Drescher, Berry, N.J., Bird, M., P. de Camargo, Peh, K S H, Arets, Eric J M M, King, D. A., França, M.B., J. Chave, Fearnside, P M, Tan, S, Chave, J, Salim, K. A., Metcalfe, D. J., Peh, K.S.H., J. Kemp, Saiz, G., Baker, TR, D. A. King, Mitchard, E. T. A., Saiz, G, Marimon, B.S., Peh, K. S. -H., Nelson, B.W., Brondizio, E S, Kassim, A.R., B. Sonké, Iida, Y., H. Wöll, Sonke, B., Banin, L., Bird, M, Hladik, A, Raventos, M.T., Djagbletey, G, N. J. Berry, T. R. Baker, Lewis, Simon L, G. Djagbletey, A. R. Kassim, Franc, M.B., França, M B, Hladik, A., Moran, E F, Metcalfe, D J, Raventos, M T, Feldpausch, T R, N. Higuchi, Nilus, R, Fearnside, P.M., Nelson, B. W., Berry, NJ, C. A. Quesada, J. Lloyd, Chave, Jerome, Domingues, T. F., Feldpausch, TR, Banin, L, Bird, Michael, Feldpausch, Ted R, Lloyd, J., Marimon, B. S., A. R. Marshall, E. Lenza, Lewis, S.L., Quesada, C.A., Quesada, C. A., Kemp, J, Brondizio, Eduardo S, Nelson, B W, G. Saiz, White, L., T. R. Feldpausch, T. F. Domingues, J. M. Reitsma, Reitsma, J M, Drescher, M., Palace, M., Schrodt, F., Lenza, E, L. Banin, M. B. França, M. Keller, Fearnside, P. M., Kemp, J., M. Bird, Domingues, T F, Baker, T. R., Arets, E. J. M. M., E. J. M. M. Arets, J. C. Lovett, Philips, O.L., Affum-Baffoe, K, Berry, N. J., Palace, M, Mitchard, E.T.A., M. O. Hunter, Reitsma, J.M., Kassim, A. R., Marimon-Junior, B. H., Patiño, S., H. E. Taedoumg, Chave, J., R. Nilus, Arets, EJMM, Lovett, J.C., Lewis, S. L., Moran, E. F., Mitchard, E T A, M. T. Raventos, Nogueira, E M, de Camargo, Plinio, B. W. Nelson   +218 more
core   +1 more source

Trees

, 2016
Gene Trees obtained by single gene and concatenated alignments: S22 (BI COI); S23 (BI 16S); S24 (BI 18S); S25 (BI 28S); S26 (BI Concatenated); S27 (ML Concatenated); S28 (Ultrametric, BEAST Concatenated)
Francesca Leasi (175724), Jon Norenburg (3240834)   +1 more
core   +2 more sources

Transcriptomic and metabolomic profiling provide novel insights into fruit development and flesh coloration in Prunus mira Koehne, a special wild peach species

BMC Plant Biology, 2019
Background Flesh color is one of the most important traits for the commercial value of peach fruit. To unravel the underlying regulatory network in Prunus mira, we performed an integrated analysis of the transcriptome and metabolome of 3 fruit types with
Hong Ying, Jian Shi, Shanshan Zhang, Gesang Pingcuo, Shuo Wang, Fan Zhao, Yongning Cui, Xiuli Zeng   +7 more
doaj   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source