Results 41 to 50 of about 1,110,706 (305)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Population structure, genetic diversity and genome-wide association analysis of the seed morphology traits in Handroanthus chrysanthus (Jacq.) s.o.grose

BMC Plant Biology
Background Handroanthus chrysanthus is a remarkable landscape tree species with significant research and development potential. However, it remains unclear whether the varieties introduced to China are one species or two species.
Xiuhua Shang, Zhihua Wu, Guowu Zhang, Youshuang Wang, Xiaoming Li, Peijian Zhang   +5 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Analysis of combining ability and heterosis based on controlled pollination populations of eucalypt

Scientific Reports
Artificial hybridization remains the most effective method for genetic improvement of eucalypt, though limited research exists on the genetic basis of heterosis for interesting traits in Chinese eucalypt.
Zhiyi Su, Wanhong Lu, Haoyang Cao, Guo Liu, Yan Lin, Anying Huang, Jianzhong Luo   +6 more
doaj   +1 more source

Adaptation to Climate Change with Forests, Trees and Agroforestry: FTA Highlights of a Decade 2011–2021

, 2021
Forest, trees and agroforestry are crucial for adaptation to climate change in two ways that make the sector unique. First, forests and trees are already affected by climate change, and their resilience to climate impacts is a prerequisite for forest and
C., Licona Manzur, A., Meybeck, V., Gitz
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Exploring the genetic basis of heterosis in eucalypt growth based on transcriptome analysis

BMC Genomics
Background The fundamental way to solve the problems of a Limited interspecific gene pool, poor stress resistance, and low yield in Chinese eucalypt plantations is to use the Heterosis derived from the eucalypt gene pool to select new varieties with rich
Zhiyi Su, Wanhong Lu, Yan Lin, Guo Liu, Anying Huang, Jianzhong Luo   +5 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

The Agroforestry Species Switchboard, a global resource to explore information for 107,269 plant species

Scientific Data
The Agroforestry Species Switchboard is a comprehensive vascular plant database that guides users to information for a particular taxon from a global but fragmented set of resources.
Roeland Kindt, Ilyas Siddique, Ian Dawson, Innocent John, Fabio Pedercini, Jens-Peter Lillesø, Lars Graudal   +6 more
doaj   +1 more source

Integrated Mitochondrial Genome and Transcriptomic Analyses Reveal Long Non-Coding RNAs Associated with Drought Tolerance in Sophora moorcroftiana

Biology
Sophora moorcroftiana is a perennial deciduous dwarf shrub that exhibits remarkable ecological adaptability, including strong drought resistance on the Tibetan Plateau. In this study, the complete mitogenome of S. moorcroftiana was reported and assembled
Jun Xu, Yan Sun, Yuting Wang, Jibin Nan, Quzhen Gesang, Bingzhang Li   +5 more
doaj   +1 more source