Autophagosome marker, LC3, is released extracellularly via several distinct pathways
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito +3 more
wiley +1 more source
Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley +1 more source
Dietary Assessment and Trends Among Preschoolers in South Korea: Data from KNHANES 2012-2021. [PDF]
Kwon YS +5 more
europepmc +1 more source
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima +4 more
wiley +1 more source
A 25-year assessment of aerosol dynamics and environmental drivers in Iran's Lakes and wetlands. [PDF]
Ebrahimi-Khusfi Z +3 more
europepmc +1 more source
Association between socioeconomic variables and carotid plaque in middle-aged adults: data from the Akershus Cardiac Examination (ACE) 1950 Study. [PDF]
Bratholm ÅO +9 more
europepmc +1 more source
Dynamic responses of gross primary productivity to compound hot extremes and drought across different geographical regions of China. [PDF]
Qin Y +5 more
europepmc +1 more source
Modified Mann-Kendall with higher-order statistics for trend analysis. [PDF]
Then YJ, Abdul Halim S.
europepmc +1 more source
Trends in mortality rates of female breast cancer in China, 2004 to 2021. [PDF]
Xiong H, Ma F.
europepmc +1 more source
Epidemiological characteristics and spatial clustering analysis of typhoid and paratyphoid fevers in China, 2014-2022. [PDF]
Xiao H, Zhao J, Qiu J, Chen S, Zhou Y.
europepmc +1 more source

