Results 121 to 130 of about 5,983,003 (293)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Trend and Driving Force Analyses of Streamflow and Sediment Discharge in Jialing River
Shuitu baochi yanjiu, 2010 The sediment discharge in Jialing River basin has decreased significantly over the past 20years.This change will have a major impact on the Yangtze River Three Gorges reservoir area of water and sediment movement and changes in sediment yield and ...
GAO Peng, MU Xing-min, WANG Wei
doaj
, 2013 R code for performing all data analyses and Figure generation in Hadfield at al.
Boris R. Krasnov (150084) +3 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Analysing global trends in employment transformation
Bulletin of "Turan" UniversityIn modern economic conditions, the labor market plays a crucial role in ensuring sustainable development of society and social stability. As a complex socio-economic system, the labor market reflects the interaction between employers and employees, determines employment conditions, wage levels, and ultimately affects the quality of life of the ...
M. B. Saruarova +3 more
openaire +1 more source
International Evidence on Monetary Neutrality Under Broken Trend Stationary Models [PDF]
We analyze the issue of the impact of multiple breaks on monetary neutrality results, using annual data on real output and monetary aggregates for Argentina (1884-1996), Australia (1870-1997), Brazil (1912-1995), Canada (1870-2001), Italy (1870-1997 ...
L.M. Soria, A.E. Noriega, R. Velazquez
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source