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Recombinant Treponema pallidum protein Tp47 promoted the phagocytosis of macrophages by activating NLRP3 inflammasome induced by PKM2‐dependent glycolysis

Journal of the European Academy of Dermatology and Venereology, 2023
Glycolysis is a critical pathway in cellular glucose metabolism that provides energy and participates in immune responses. However, whether glycolysis is involved in NOD‐like receptor family protein 3 (NLRP3) inflammasome activation and phagocytosis of ...
Y. Zheng   +8 more
semanticscholar   +1 more source

Virulence and Adhesion of the Treponema pallidum Nichols Strain Simultaneously Decrease in a Continuous-Infection New Zealand White Rabbit Model.

ACS Infectious Diseases, 2023
Syphilis is a sexually transmitted disease caused by T. pallidum, and the T. pallidum Nichols strain is widely used with the New Zealand white rabbit model for evaluating drug and vaccine protection. However, changes in the virulence of T.
Jialin Huang   +13 more
semanticscholar   +1 more source

Molecular and Direct Detection Tests for Treponema pallidum Subspecies pallidum: A Review of the Literature, 1964–2017

open access: yesClinical Infectious Diseases, 2020
Direct detection methods for Treponema pallidum include dark-field microscopy (DFM), direct fluorescence antibody (DFA) testing, immunohistochemistry (IHC), and nucleic acid amplification tests (NAATs).
Samantha Katz   +2 more
exaly   +2 more sources

Treponema pallidum detection in lesion and non-lesion sites in men who have sex with men with early syphilis: a prospective, cross-sectional study.

Lancet. Infectious Diseases (Print), 2021
BACKGROUND Syphilis transmission is increasing, and precisely how Treponema pallidum is transmitted sexually from person to person is unclear. We aimed to determine the frequency of T pallidum shedding from potentially asymptomatic sites and the stage of
J. Towns   +11 more
semanticscholar   +1 more source

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