Results 231 to 240 of about 3,371,113 (299)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Scandinavian Displaced Lateral Clavicle trial (ScanDiLaC): a study protocol for a randomized clinical trial. [PDF]

Trials
Christersson P, Karimi D, Grønhaug K, Launonen A, Brorson S, Frihagen F, Viberg B, Hailer N, Wolf O.   +8 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Do we consider scalability from the outset? A methodological review of pilot randomised controlled health trials. [PDF]

BMJ Open
Mclaughlin M, Toll K, Myers B, Riddell H, Moullin J, Reid CM, Quested E, McDonald MD.   +7 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Expectations and Motivations for Participation in Clinical Trials Utilizing Psychedelics for Treatment-Resistant Depression: A Qualitative Study. [PDF]

Brain Behav
Poppe C, Lyck L, Bechtold L, Repantis D.
europepmc   +1 more source

Examining the Impact of Trial Length on Detecting Medication Effects for Alcohol Use Disorder: A Meta-Regression Study. [PDF]

Alcohol Clin Exp Res (Hoboken)
Belnap MA, Witkiewitz K, Schacht JP, Anton RF, Aldridge AP, Nieto SJ, Ray LA.   +6 more
europepmc   +1 more source

"Protected time" for clinical investigators in medical oncology: The persistent gap between expectation and reality. [PDF]

Cancer
Sedrak MS, Ramalingam SS, Sparano JA.
europepmc   +1 more source

Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE): A Protocol for a Pre-Planned Sub-Study of a Randomized Clinical Trial. [PDF]

Acta Anaesthesiol Scand
M KK, V H N, P Y, N N, M P W, M R, F B, G L, J D, N H, J H, H L, M MK, M S, M T, A C, C B K, C D B S, D A, S S, J T, T O, H S, S B, J D, A L, J J, J U, A L, J K, J G, E L, L R, P S, P S, T G, A M, C L, J N, P D, K A, P J M, J W, M G, M O, P H, A P, R H, D P, P J, A N, M H, M P H, M I, C S, M N, M J, C R, J B, D R, Y A, A AF, C YW, A A, A S, C A, M R, R P, A D, M R, B V, F T, P T P, H F, T C, J C J, M B S.   +76 more
europepmc   +1 more source

Journal of the American Trial Lawyers Association

, 1965
American Trial Lawyers Association
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