Results 291 to 300 of about 7,719,266 (361)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Protocol and statistical designs in classic clinical research-toripalimab series trial analysis. [PDF]

Cancer Biol Med
He Y, Bian L, Jiang Z.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Tailored Exercise Strategies and Mortality Among Breast Cancer Survivors.

JAMA Netw Open
Jayasekera J, Ergas IJ, Schneider J, Tian E, Wojcik KM, Roh JM, Vo JB, Kushi LH, Wilson OWA, McGee EE.   +9 more
europepmc   +1 more source

Exploring scalable assessment methods for terminated trials in ClinicalTrials.gov: A cohort analysis of German and Californian trials. [PDF]

PLoS One
Yerunkar SS, Carlisle BG, Franzen DL, Salholz-Hillel M, Strech D, Schorr SG.   +5 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Acetylcholine demixes heterogeneous dopamine signals for learning and moving. [PDF]

Nat Neurosci
Jang HJ, McMahon Ward R, Golden CEM, Constantinople CM.   +3 more
europepmc   +1 more source

Blood eosinophil count as a biomarker for therapy guidance in COPD and asthma exacerbations. [PDF]

Breathe (Sheff)
Godallage AN, Afrose D, Valizadeh M, Beech A, Jensen JS, Sivapalan P.   +5 more
europepmc   +1 more source

Bayesian reanalysis of early remdesivir for the treatment of COVID-19 in outpatients with high risk of progression to severe disease. [PDF]

PLoS One
Abdelghany M, Yu F, Rennard S, Gwon Y.
europepmc   +1 more source