Results 61 to 70 of about 397,654 (324)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Aspects of the Jury in Criminal Proceedings [PDF]

open access: yes, 2018
Although a trial by jury happens in only a fraction of the total criminal cases, the jury is one of the most intriguing facets of criminal proceedings. This thesis intends to delve into the various aspects of the criminal jury’s history, formulation, and
Akers, Hannah
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

FREEDOM OF PRESS AND JURY TRIAL IN ISTRIA 1848/1849

open access: yesZbornik Pravnog Fakulteta Sveučilišta u Rijeci, 2015
In Istria, as a part of the Austrian legal system, jury trial was initially introduced in the revolutionary year of 1848 only for press offenses, in the framework of aspirations for freedom of thought and expression through the press, which represented ...
Dunja Pastović
doaj  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Expert-lay interaction in jury trials (case study of closing arguments)

open access: yesJournal of Language and Cultural Education, 2017
This study arises out of the intention to examine the features of expert-lay interaction in a jury trial. The paper studies closing arguments constructed by legal experts as possible worlds which would be attractive for jurors.
Krapivkina Olga A.
doaj   +1 more source

\u3cem\u3eUnited States v. The William\u3c/em\u3e and The Phenomena of Jury Nullification in Early 19th Century America [PDF]

open access: yes, 2017
In September 1808, Judge John Davis upheld the constitutionality of the Embargo Act of 1807 under the Constitution’s Article I, Section 8, Clause 3 Interstate Commerce power.
Lederman, Michael G.
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Jury selection and jury trial in Spain: between theory and practice

open access: yesOñati Socio-Legal Series, 2012
The Jury Court in Spain is composed of nine citizens and is headed by a magistrate belonging to the Provincial Court, Chamber of Criminal. These citizens participate as lay assessors in a very particular way. The Spanish Jury Law 5/1995 contemplates its
Mar Jimeno-Bulnes
doaj  

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