Changes in prescribed medicines in older patients with multimorbidity and polypharmacy in general practice [PDF]
, 2018 Background: Treatment complexity rises in line with the number of drugs, single doses, and administration methods, thereby threatening patient adherence. Patients with multimorbidity often need flexible, individualised treatment regimens, but alterations
Buedingen, Fiona von +5 more
core +1 more source
The promoter polymorphism -232C/G of the PCK1 gene is associated with type 2 diabetes in a UK-resident South Asian population [PDF]
, 2009 Background: The PCK1 gene, encoding cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C), has previously been implicated as a candidate gene for type 2 diabetes (T2D) susceptibility.
A Valera +24 more
core +6 more sources
Don’t turn your back on the symptoms of psychosis : a proof-of-principle, quasi-experimental public health trial to reduce the duration of untreated psychosis in Birmingham, UK [PDF]
, 2013 Background: Reducing the duration of untreated psychosis (DUP) is an aspiration of international guidelines for first episode psychosis; however, public health initiatives have met with mixed results.
A Malla +32 more
core +4 more sources
Current Controlled Trials in Cardiovascular Medicine, 2000 Some problems with the quality of controlled clinical trials can be addressed by following these procedures: registering all trials at inception; using systematic reviews to inform the design of new studies; posting and obtaining feedback on preprints ...
Chalmers Iain
doaj +1 more source
Clinical Trial Registration: The Time Has Come… [PDF]
Archives of Physical Medicine and Rehabilitation, 2015 Note from the BJOT Editor-Chief BJOT, like many major occupational therapy and rehabilitation journals, has already adopted guidelines for reporting. Since 2015, when the journal moved to SAGE for publication, BJOT has conformed to the ICMJE requirement ( International Committee of Medical Journal Editors[ICMJE], n.d.
Leighton, Chan, Allen W, Heinemann
openaire +8 more sources
Royal Society Open Science, 2022 Undisclosed discrepancies often exist between study registrations and their associated publications. Discrepancies can increase risk of bias, and when undisclosed, they disguise this increased risk of bias from readers. To remedy this issue, we developed
doaj +1 more source
Microbicides development programme: engaging the community in the standard of care debate in a vaginal microbicide trial in Mwanza, Tanzania. [PDF]
, 2009 BACKGROUND: HIV prevention research in resource-limited countries is associated with a variety of ethical dilemmas. Key amongst these is the question of what constitutes an appropriate standard of health care (SoC) for participants in HIV prevention ...
Changalucha, John +11 more
core +2 more sources
Factors associated with alcohol reduction in harmful and hazardous drinkers following alcohol brief intervention in Scotland: a qualitative enquiry [PDF]
, 2017 Background: Alcohol Brief Intervention (ABI) uses a motivational counselling approach to support individuals to reduce excessive alcohol consumption. There is growing evidence on ABI’s use within various health care settings, although how they work and
AC Mcfarlane +21 more
core +3 more sources
Targeted, structured text messaging to improve dietary and lifestyle behaviours for people on maintenance haemodialysis (KIDNEYTEXT): Study protocol for a randomised controlled trial [PDF]
, 2019 Introduction Managing nutrition is critical for reducing morbidity and mortality in patients on haemodialysis but adherence to the complex dietary restrictions remains problematic.
Brown, Mark +12 more
core +1 more source
Effect of tart cherry juice on risk of gout attacks: protocol for a randomised controlled trial [PDF]
, 2020 Introduction: Gout is a painful form of inflammatory arthritis associated with several comorbidities, particularly cardiovascular disease. Cherries, which are rich in anti-inflammatory and antioxidative bioactive compounds, are proposed to be efficacious
Barker, Margo E +3 more
core +2 more sources