Results 31 to 40 of about 389,425 (138)

Comparison of published orthopaedic trauma trials following registration in Clinicaltrials.gov

BMC Musculoskeletal Disorders, 2011
Background After the Food and Drug Administration Modernization Act of 1997, the registration of all clinical trials became mandatory prior to publication.
Gandhi Rajiv, Jan Meryam, Smith Holly N, Mahomed Nizar N, Bhandari Mohit   +4 more
doaj   +1 more source

Prospective trial registration and publication rates of randomized clinical trials in digital health: A cross-sectional analysis of global trial registries

Digital Health, 2022
Objectives We sought to examine the prevalence of prospective registration and publication rates in digital health trials. Materials and Methods We included 417 trials that enrolled participants in 2012 and were registered in any of the 17 WHO data ...
Mustafa Al-Durra, Robert P Nolan, Emily Seto, Joseph A Cafazzo   +3 more
doaj   +1 more source

Adherence to the International Committee of Medical Journal Editors’ (ICMJE) prospective registration policy and implications for outcome integrity: a cross-sectional analysis of trials published in high-impact specialty society journals

Trials, 2018
Background Registration of clinical trials is critical for promoting transparency and integrity in medical research; however, trials must be registered in a prospective fashion to deter unaccounted protocol modifications or selection of alternate ...
Anand D. Gopal, Joshua D. Wallach, Jenerius A. Aminawung, Gregg Gonsalves, Rafael Dal-Ré, Jennifer E. Miller, Joseph S. Ross   +6 more
doaj   +1 more source

Problems of subgroup analysis in randomized controlled trial

BMC Anesthesiology, 2020
Multiple subgroup analyses of the same data increase the risk of generating false positive findings. All outcomes and planned subgroup analyses should thus be prespecified and described in the original trial registry.
Hans-Joachim Priebe
doaj   +1 more source

Compliance with clinical trial registration and reporting guidelines by Latin American and Caribbean journals [PDF]

Cadernos de Saúde Pública, 2013
The objective of this study was to determine to what extent Latin American and Caribbean biomedical journals have endorsed and complied with clinical trial registration and reporting guidelines.
Ludovic Reveiz, Eleana Villanueva, Chimaraoke Iko, Iveta Simera   +3 more
doaj   +1 more source

Evaluating the current landscape of clinical trials registration and results reporting policies, procedures and staffing at US-based academic centers: Survey revisited

Journal of Clinical and Translational Science
Introduction: Historically US-based academic organizations dedicated limited resources, including policies, personnel to ensuring compliance with clinical trials registration and results reporting requirements.
Anthony Keyes, Jesse Reynolds, Jillian Barron, Sarah White   +3 more
doaj   +1 more source

Issues with reporting and interpretation of Khan et al. 2021

BMC Infectious Diseases, 2022
A recent publication in BMC Infectious Diseases concerning the use of convalescent plasma for the treatment of COVID-19 had a number of major issues.
Nicholas J. DeVito, Henry Drysdale
doaj   +1 more source

A polyvalent DNA prime with matched polyvalent protein/GLA-SE boost regimen elicited the most robust and broad IgG and IgG3 V1V2 binding antibody and CD4+ T cell responses among 13 HIV vaccine trials

Emerging Microbes and Infections
Developing an effective HIV vaccine is a momentous challenge. An exceptionally wide range of candidate HIV vaccines have been tested, yet many were poorly immunogenic, and of the select few that advanced into efficacy trials, only one demonstrated any ...
Zoe Moodie, Shuying Sue Li, Elena E. Giorgi, LaTonya D. Williams, One Dintwe, Lindsay N. Carpp, Shiyu Chen, Kelly E. Seaton, Sheetal S. Sawant, Lu Zhang, Jack Heptinstall, Shuying Liu, Nicole Grunenberg, Frank Tomaka, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Julie A. Ake, Sandhya Vasan, Giuseppe Pantaleo, Ian Frank, Lindsey R. Baden, Paul A. Goepfert, Michael Keefer, Mike Chirenje, Mina C. Hosseinipour, Kathryn Mngadi, Fatima Laher, Nigel Garrett, Linda-Gail Bekker, Stephen De Rosa, Erica Andersen-Nissen, James G. Kublin, Shan Lu, Peter B. Gilbert, Glenda E. Gray, Lawrence Corey, M. Juliana McElrath, Georgia D. Tomaras   +38 more
doaj   +1 more source

Randomized controlled trial about pain medication flupirtine ignores recent pharmacovigilance warnings

Journal of Pain Research, 2018
Livia Puljak1,2 1Laboratory for Pain Research, University of Split School of Medicine, Split, Croatia; 2Department for Development, Research and Health Technology Assessment, Agency for Quality and Accreditation in Health Care and Social Welfare, Zagreb,
Puljak L
doaj  

Registration of noncommercial randomised clinical trials: the feasibility of using trial registries to monitor the number of trials

Trials, 2012
Background A 2003 survey suggested the number of noncommercial trials in the UK was declining. Formation of the NIHR in 2006 and increased research spending by the Department of Health may have increased the number of noncommercial trials but no data are
Raftery James, Fairbank Eleanor, Douet Lisa, Dent Louise, Price Alison, Milne Ruairidh, Walley Tom   +6 more
doaj   +1 more source