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The Design and Analysis of Sequential Clinical Trials.
Biometrics, 1983Clinical Trials. Allocating Patients to Treatments. Measurement of Treatment Difference. The Design of a Sequential Trial Using the Boundaries Approach. The Analysis of a Sequential Trial. Alternative Approaches to the Design and Analysis of Sequential Clinical Trials. Prognostic Factors. The Comparison of More than Two Treatments.
R. J. Prescott, J. Whitehead
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A New Procedure for Group Sequential Analysis in Clinical Trials
Biometrics, 1992Since Pocock (1977, Biometrika 64, 191-199), many methods have been developed for group sequential analysis of clinical trials. However, these methods remain underemployed partly because of inconsistencies of sequential testing [Berry (1987, The Statistician 36, 181-189)].
Falissard, Bruno, Lellouch, Joseph
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Bayesian sequential analysis for multiple-arm clinical trials
Statistics and Computing, 2008Use of full Bayesian decision-theoretic approaches to obtain optimal stopping rules for clinical trial designs typically requires the use of Backward Induction. However, the implementation of Backward Induction, apart from simple trial designs, is generally impossible due to analytical and computational difficulties.
Luke Akong’o Orawo +1 more
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Analysis of Sequential Clinical Trials
2012We discuss issues and methods for the analysis of clinical trials that have formal rules for what is commonly referred to as early stopping. However, we take a broader view, and include trials having a formal sequential stopping rule; the distinction will soon become apparent.
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Vitamin D supplementation and falls: a trial sequential meta-analysis
The Lancet Diabetes & Endocrinology, 2014Vitamin D supplementation is often recommended to prevent falls, although vitamin D trials and meta-analyses of these trials have reported conflicting results for this outcome. We aimed to assess if there was a need for further research.We explored the value of doing further randomised controlled trials assessing the effects of vitamin D supplements on
Mark J, Bolland +3 more
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Incorporation of sequential trials into a fixed effects meta‐analysis
Statistics in Medicine, 1997The technique of meta-analysis provides a systematic and quantitative approach to the summary of results from a collection of similar randomized studies. Comprehensive methodology exists for analysis when all trials are of a fixed sample size design, but this is based on assumptions which are no longer valid when incorporating sequentially designed ...
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Supplementary Analysis at the Conclusion of a Sequential Clinical Trial
Biometrics, 1986Suppose that a clinical trial has been carried out using a sequential design. Any analysis that neglects the monitoring of the trial is potentially biased, and this holds for analyses of responses not directly used to determine whether the study should be stopped.
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Sequential Analysis with Applications to Clinical Trials
2012The topic of the thesis is an overview of some sequential and change-point detection methods with applications to clinical trials. Performing sequential monitoring is important for ethical, economical and other reasons. It is important to terminate a study as soon as possible when potentially harmful treatments are used or when financial resources are ...
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Interpreting trial sequential analysis
Transfusion, 2016Chatree Chai‐Adisaksopha +2 more
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Trial Sequential Analysis in Critical Care Medicine: The Way Forward
Critical Care Medicine, 2022Lew, Charles Chin Han +2 more
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